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Buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats

Overview of attention for article published in Neuropsychiatric Disease and Treatment, March 2015
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Title
Buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats
Published in
Neuropsychiatric Disease and Treatment, March 2015
DOI 10.2147/ndt.s70585
Pubmed ID
Authors

Shao-Tsu Chen, Hwei-Hsien Chen, Yao-Chang Chiang, Zung Fan Yuan, Chung-Chih Kuo, Mei-Dan Lai, Tsai-Wei Hung, Ing-kang Ho

Abstract

Methadone and buprenorphine are widely used for treating people with opioid dependence, including pregnant women. Prenatal exposure to opioids has devastating effects on the development of human fetuses and may induce long-term physical and neurobehavioral changes during postnatal maturation. This study aimed at comparing the behavioral outcomes of young rats prenatally exposed to buprenorphine, methadone, and morphine. Pregnant Sprague-Dawley rats were administered saline, morphine, methadone, and buprenorphine during embryonic days 3-20. The cognitive function, social interaction, anxiety-like behaviors, and locomotor activity of offsprings were examined by novel object recognition test, social interaction test, light-dark transition test, elevated plus-maze, and open-field test between 6 weeks and 10 weeks of age. Prenatal exposure to methadone and buprenorphine did not affect locomotor activity, but significantly impaired novel object recognition and social interaction in both male and female offsprings in the same manner as morphine. Although prenatal exposure to methadone or buprenorphine increased anxiety-like behaviors in the light-dark transition in both male and female offsprings, the effects were less pronounced as compared to that of morphine. Methadone affected elevated plus-maze in both sex, but buprenorphine only affected the female offsprings. These findings suggest that buprenorphine and methadone maintenance therapy for pregnant women, like morphine, produced detrimental effects on cognitive function and social behaviors, whereas the offsprings of such women might have a lower risk of developing anxiety disorders.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 17%
Student > Bachelor 6 12%
Student > Master 6 12%
Researcher 5 10%
Other 4 8%
Other 9 17%
Unknown 13 25%
Readers by discipline Count As %
Medicine and Dentistry 9 17%
Neuroscience 7 13%
Agricultural and Biological Sciences 6 12%
Psychology 6 12%
Biochemistry, Genetics and Molecular Biology 4 8%
Other 6 12%
Unknown 14 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2017.
All research outputs
#10,016,520
of 12,517,383 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,641
of 2,120 outputs
Outputs of similar age
#160,793
of 232,479 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#44
of 46 outputs
Altmetric has tracked 12,517,383 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,120 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,479 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.