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Cetuximab-conjugated iron oxide nanoparticles for cancer imaging and therapy

Overview of attention for article published in International Journal of Nanomedicine, May 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

twitter
3 tweeters
patent
1 patent

Citations

dimensions_citation
46 Dimensions

Readers on

mendeley
70 Mendeley
Title
Cetuximab-conjugated iron oxide nanoparticles for cancer imaging and therapy
Published in
International Journal of Nanomedicine, May 2015
DOI 10.2147/ijn.s80134
Pubmed ID
Authors

I-Ming Chu, Shih-Heng Tseng, Min-Yuan Chou

Abstract

We have developed a theranostic nanoparticle, ie, cet-PEG-dexSPIONs, by conjugation of the anti-epidermal growth factor receptor (EGFR) monoclonal antibody, cetuximab, to dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) via periodate oxidation. Approximately 31 antibody molecules were conjugated to each nanoparticle. Cet-PEG-dexSPIONs specifically bind to EGFR-expressing tumor cells and enhance image contrast on magnetic resonance imaging. Cet-PEG-dexSPION-treated A431 cells showed significant inhibition of epidermal growth factor-induced EGFR phosphorylation and enhancement of EGFR internalization and degradation. In addition, a significant increase in apoptosis was detected in EGFR-overexpressing cell lines, A431 and 32D/EGFR, after 24 hours of incubation at 37°C with cet-PEG-dexSPIONs compared with cetuximab alone. The antibody-dependent cell-mediated cytotoxicity of cetuximab was observed in cet-PEG-dexSPIONs. The results demonstrated that cet-PEG-dexSPIONs retained the therapeutic effect of cetuximab in addition to having the ability to target and image EGFR-expressing tumors. Cet-PEG-dexSPIONs represent a promising targeted magnetic probe for early detection and treatment of EGFR-expressing tumor cells.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 1%
Unknown 69 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 24%
Researcher 17 24%
Student > Master 12 17%
Student > Bachelor 5 7%
Professor 4 6%
Other 8 11%
Unknown 7 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 24%
Chemistry 12 17%
Pharmacology, Toxicology and Pharmaceutical Science 8 11%
Agricultural and Biological Sciences 8 11%
Medicine and Dentistry 4 6%
Other 11 16%
Unknown 10 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2018.
All research outputs
#3,837,291
of 14,824,038 outputs
Outputs from International Journal of Nanomedicine
#301
of 2,833 outputs
Outputs of similar age
#59,320
of 233,130 outputs
Outputs of similar age from International Journal of Nanomedicine
#4
of 62 outputs
Altmetric has tracked 14,824,038 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 2,833 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,130 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.