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Dove Medical Press

Value of phagocyte function screening for immunotoxicity of nanoparticles in vivo

Overview of attention for article published in International Journal of Nanomedicine, May 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

policy
1 policy source
twitter
3 X users
facebook
1 Facebook page

Citations

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40 Dimensions

Readers on

mendeley
72 Mendeley
Title
Value of phagocyte function screening for immunotoxicity of nanoparticles in vivo
Published in
International Journal of Nanomedicine, May 2015
DOI 10.2147/ijn.s83068
Pubmed ID
Authors

Eleonore Fröhlich

Abstract

Nanoparticles (NPs) present in the environment and in consumer products can cause immunotoxic effects. The immune system is very complex, and in vivo studies are the gold standard for evaluation. Due to the increased amount of NPs that are being developed, cellular screening assays to decrease the amount of NPs that have to be tested in vivo are highly needed. Effects on the unspecific immune system, such as effects on phagocytes, might be suitable for screening for immunotoxicity because these cells mediate unspecific and specific immune responses. They are present at epithelial barriers, in the blood, and in almost all organs. This review summarizes the effects of carbon, metal, and metal oxide NPs used in consumer and medical applications (gold, silver, titanium dioxide, silica dioxide, zinc oxide, and carbon nanotubes) and polystyrene NPs on the immune system. Effects in animal exposures through different routes are compared to the effects on isolated phagocytes. In addition, general problems in the testing of NPs, such as unknown exposure doses, as well as interference with assays are mentioned. NPs appear to induce a specific immunotoxic pattern consisting of the induction of inflammation in normal animals and aggravation of pathologies in disease models. The evaluation of particle action on several phagocyte functions in vitro may provide an indication on the potency of the particles to induce immunotoxicity in vivo. In combination with information on realistic exposure levels, in vitro studies on phagocytes may provide useful information on the health risks of NPs.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 1%
Unknown 71 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 24%
Unspecified 11 15%
Researcher 7 10%
Student > Doctoral Student 6 8%
Student > Bachelor 5 7%
Other 11 15%
Unknown 15 21%
Readers by discipline Count As %
Unspecified 11 15%
Medicine and Dentistry 8 11%
Agricultural and Biological Sciences 8 11%
Immunology and Microbiology 7 10%
Biochemistry, Genetics and Molecular Biology 7 10%
Other 14 19%
Unknown 17 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 April 2020.
All research outputs
#7,205,295
of 25,374,647 outputs
Outputs from International Journal of Nanomedicine
#765
of 4,123 outputs
Outputs of similar age
#79,824
of 278,920 outputs
Outputs of similar age from International Journal of Nanomedicine
#14
of 89 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 4,123 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,920 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.