Title |
Risk definition and management strategies in retinoblastoma: current perspectives
|
---|---|
Published in |
Clinical Ophthalmology, June 2015
|
DOI | 10.2147/opth.s59828 |
Pubmed ID | |
Authors |
Fariba Ghassemi, Alireza Khodabande |
Abstract |
This manuscript focuses on high-risk factors of metastatic disease in retinoblastoma and evaluation of the current treatments of retinoblastoma. Presence of histopathologic high-risk factors is associated with a higher risk of local recurrence and systemic metastasis. Currently, globe-sparing therapies, including systemic chemotherapy, intra-arterial chemoreduction, intravitreal chemotherapy, focal consolidation, and combination therapies, are being used and investigated actively. Major advances are being made in the diagnosis and management of retinoblastoma that will lead to improved morbidity and mortality rates in patients with retinoblastoma. By saving the globes, fronting with some high-risk factors for metastasis would be inevitable. International multi-institutional prospective studies could resolve current uncertainties regarding the main tumor treatment regimens for each patient and indications for chemoprophylaxis for high-risk-factor-bearing retinoblastoma cases. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 69 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Postgraduate | 9 | 13% |
Student > Bachelor | 9 | 13% |
Student > Ph. D. Student | 8 | 12% |
Other | 7 | 10% |
Researcher | 7 | 10% |
Other | 17 | 25% |
Unknown | 12 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 37 | 54% |
Nursing and Health Professions | 6 | 9% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Agricultural and Biological Sciences | 3 | 4% |
Immunology and Microbiology | 1 | 1% |
Other | 4 | 6% |
Unknown | 14 | 20% |