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Protective effect of galangin in Concanavalin A- induced hepatitis in mice

Overview of attention for article published in Drug Design, Development and Therapy, June 2015
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Title
Protective effect of galangin in Concanavalin A- induced hepatitis in mice
Published in
Drug Design, Development and Therapy, June 2015
DOI 10.2147/dddt.s80979
Pubmed ID
Authors

Fuxiang Chen, Qingqiong Luo, Liping Zhu, Jieying Ding, Xing Zhuang, Lili Xu

Abstract

Galangin is an active pharmacological ingredient from propolis and Alpinia officinarum Hance, and has been reported to have anti-inflammatory and antioxidative properties. The present study aims to reveal the effect of galangin on Concanavalin A (ConA)-induced hepatitis (CIH), a well-established animal model of immune-mediated liver injury, and to clarify the related mechanism. C57BL/6 mice were pretreated with galangin followed by ConA challenge. Results indicated that galangin inhibited ConA-induced liver damage. Mice pretreated with galangin showed more reduction of liver damage when compared with control mice pretreated with vehicle solution. In galangin-pretreated mice with induced CIH, increases in serum levels of several inflammatory cytokines, including tumor necrosis factor-α, interferon-γ, and interleukin-12 were dramatically attenuated, and chemokines and adhesion molecules like interferon inducible protein-10, macrophage inflammatory protein-1α, and inter-cellular adhesion molecule-1 messenger RNA expressions in liver were decreased. Moreover, CIH mice pretreated with galangin showed less leukocyte infiltration and T-cell activation in the liver. Further, the mechanism of the anti-inflammatory effects of galangin may be attributed to its modulation of crucial inflammatory signaling pathways, including nuclear factor kappa B and interferon-gamma/signal transducer and activator of transcription 1. Collectively, these findings suggest the preventive and therapeutic potential of galangin in immune-mediated liver injury in vivo.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 22%
Student > Doctoral Student 4 15%
Researcher 3 11%
Student > Ph. D. Student 3 11%
Lecturer 2 7%
Other 6 22%
Unknown 3 11%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 7 26%
Biochemistry, Genetics and Molecular Biology 4 15%
Agricultural and Biological Sciences 3 11%
Chemistry 3 11%
Medicine and Dentistry 3 11%
Other 3 11%
Unknown 4 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2015.
All research outputs
#4,341,266
of 5,214,302 outputs
Outputs from Drug Design, Development and Therapy
#533
of 776 outputs
Outputs of similar age
#144,172
of 176,838 outputs
Outputs of similar age from Drug Design, Development and Therapy
#84
of 119 outputs
Altmetric has tracked 5,214,302 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 776 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,838 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 119 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.