Title |
Treatment of refractory/relapsed adult acute lymphoblastic leukemia with bortezomib- based chemotherapy
|
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Published in |
International Journal of General Medicine, June 2015
|
DOI | 10.2147/ijgm.s59537 |
Pubmed ID | |
Authors |
Junmei Zhao, Chao Wang, Yongping Song, Yuzhang Liu, Baijun Fang |
Abstract |
Nine pretreated patients aged >19 years with relapsed/refractory acute lymphoblastic leukemia (ALL) were treated with a combination of bortezomib plus chemotherapy before allogeneic hematopoietic stem cell transplantation (allo-HSCT). Eight (88.9%) patients, including two Philadelphia chromosome-positive ALL patients, achieved a complete remission. Furthermore, the evaluable patients have benefited from allo-HSCT after response to this reinduction treatment. We conclude that bortezomib-based chemotherapy was highly effective for adults with refractory/relapsed ALL before allo-HSCT. Therefore, this regimen deserves a larger series within prospective trials to confirm these results. |
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Unknown | 14 | 100% |
Demographic breakdown
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Unknown | 4 | 29% |
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