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Neuroprotective and antioxidant effects of ghrelin in an experimental glaucoma model

Overview of attention for article published in Drug Design, Development and Therapy, June 2015
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Title
Neuroprotective and antioxidant effects of ghrelin in an experimental glaucoma model
Published in
Drug Design, Development and Therapy, June 2015
DOI 10.2147/dddt.s83067
Pubmed ID
Authors

Onur Catak, Nagehan Can, Burak Turgut, Tamer Demir, Nevin Ilhan, Tuncay Kuloglu, Ibrahim Hanifi Ozercan

Abstract

Damage to retinal ganglion cells due to elevation of intraocular pressure (IOP) is responsible for vision loss in glaucoma. Given that loss of these cells is irreversible, neuroprotection is crucial in the treatment of glaucoma. In this study, we investigated the possible antioxidant and neuroprotective effects of ghrelin on the retina in an experimental glaucoma model. Twenty-one Sprague-Dawley rats were randomly assigned to three groups comprising seven rats each. The rats in the control group were not operated on and did not receive any treatment. In all rats in the other groups, IOP was increased by cauterization of the limbal veins. After creation of the IOP increase, saline 1 mL/kg or ghrelin 40 μg/kg was administered intraperitoneally every day for 14 days in the vehicle control group and ghrelin groups, respectively. On day 14 of the study, the eyes were enucleated. Levels of malondialdehyde (MDA), nitric oxide (NO), and nitric oxide synthase-2 (NOS2) in anterior chamber fluid were measured. The retinas were subjected to immunohistochemistry staining for glial fibrillary acidic protein (GFAP), S-100, and vimentin expression. Mean levels of MDA, NO, and NOS2 in the aqueous humor were higher in the vehicle control group than in the control group (P<0.05). Mean levels of MDA, NO, and NOS2 in the ghrelin group did not show a significant increase compared with levels in the control group (P>0.05). Retinal TUNEL and immunohistochemistry staining in the vehicle control group showed an increase in apoptosis and expression of GFAP, S-100, and vimentin compared with the control group (P<0.05). In the ghrelin group, apoptosis and expression of GFAP, S-100, and vimentin was significantly lower than in the vehicle control group (P<0.05). This study suggests that ghrelin has antioxidant and neuroprotective effects on the retina in an experimental glaucoma model.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hungary 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 22%
Student > Bachelor 3 17%
Researcher 3 17%
Professor 2 11%
Student > Doctoral Student 1 6%
Other 4 22%
Unknown 1 6%
Readers by discipline Count As %
Medicine and Dentistry 6 33%
Neuroscience 4 22%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Computer Science 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 2 11%
Unknown 3 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2015.
All research outputs
#20,280,315
of 22,813,792 outputs
Outputs from Drug Design, Development and Therapy
#1,578
of 2,083 outputs
Outputs of similar age
#223,473
of 267,530 outputs
Outputs of similar age from Drug Design, Development and Therapy
#97
of 125 outputs
Altmetric has tracked 22,813,792 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,083 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,530 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.