Title |
Response to rapamycin analogs but not PD-1 inhibitors in PTEN-mutated metastatic non-small-cell lung cancer with high tumor mutational burden
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Published in |
Lung Cancer: Targets and Therapy, May 2018
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DOI | 10.2147/lctt.s161738 |
Pubmed ID | |
Authors |
Ankur R Parikh, Siraj M Ali, Alexa B Schrock, Lee A Albacker, Vincent A Miller, Phil J Stephens, Pamela Crilley, Maurie Markman |
Abstract |
In non-small-cell lung cancer (NSCLC) refractory to standard therapy and which lacks well-known oncogenic drivers, genomic profiling can still identify genomic alterations that may suggest potential sensitivity to targeted therapy. PTEN mutation in NSCLC may be sensitizing to analogs of rapamycin such as everolimus or temsirolimus, but more investigation is needed. We report the case of a patient with metastatic NSCLC harboring a PTEN mutation as well as high tumor mutational burden and PD-L1 positivity with a durable response to temsirolimus, but refractory to a checkpoint inhibitor. Even in the event of failure of treatment with checkpoint inhibitors in the background of a case with a higher tumor mutational burden and PD-L1 positivity, targeting specific genomic alterations may still result in patient benefit. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 21% |
Researcher | 3 | 13% |
Student > Doctoral Student | 2 | 8% |
Student > Postgraduate | 2 | 8% |
Student > Bachelor | 2 | 8% |
Other | 3 | 13% |
Unknown | 7 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 25% |
Biochemistry, Genetics and Molecular Biology | 3 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
Nursing and Health Professions | 1 | 4% |
Unspecified | 1 | 4% |
Other | 0 | 0% |
Unknown | 11 | 46% |