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Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair

Overview of attention for article published in International Journal of Nanomedicine, June 2015
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Mentioned by

twitter
3 tweeters

Citations

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5 Dimensions

Readers on

mendeley
13 Mendeley
Title
Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair
Published in
International Journal of Nanomedicine, June 2015
DOI 10.2147/ijn.s82486
Pubmed ID
Authors

Fengqian Li, Wen Wu, Li Xiang, Hua Hong, Hong Jiang, Jun Qian, Gan Weng

Abstract

Nanoporous magnesium-zinc-silicon (n-MZS) xerogels with a pore size ∼4 nm, a surface area of 718 cm(2)/g, and a pore volume of 1.24 cm(3)/g were synthesized by a sol-gel method. The n-MZS xerogels had high capacity to load vancomycin hydrochloride (VH) and human bone morphogenetic protein-2 (rhBMP-2), after soaking in phosphate buffered saline (PBS) for 24 hours (1.5 and 0.8 mg/g, respectively). Moreover, the n-MZS xerogels exhibited the sustained release of VH and rhBMP-2 as compared with magnesium-zinc-silicon (MZS) xerogels without nanopores (showing a burst release). The VH/rhBMP-2/n-MZS system not only exhibited a good antibacterial property but also promoted the MG63 cell proliferation and differentiation demonstrating good bactericidal activity and cytocompatibility. The results suggested that n-MZS with larger surface area and high pore volume might be a promising carrier for loading and sustained release of VH and rhBMP-2. Hence, the VH/rhBMP-2/n-MZS system might be one of the promising biomaterials for osteomyelitis treatment and bone repair.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 23%
Researcher 2 15%
Student > Postgraduate 2 15%
Student > Ph. D. Student 1 8%
Student > Doctoral Student 1 8%
Other 2 15%
Unknown 2 15%
Readers by discipline Count As %
Materials Science 3 23%
Medicine and Dentistry 2 15%
Agricultural and Biological Sciences 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Environmental Science 1 8%
Other 1 8%
Unknown 4 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2015.
All research outputs
#2,612,172
of 5,268,528 outputs
Outputs from International Journal of Nanomedicine
#497
of 1,386 outputs
Outputs of similar age
#93,497
of 185,423 outputs
Outputs of similar age from International Journal of Nanomedicine
#51
of 117 outputs
Altmetric has tracked 5,268,528 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,386 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 185,423 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 117 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.