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The social functional outcome of being naturalistically treated with paliperidone extended-release in patients with schizophrenia

Overview of attention for article published in Neuropsychiatric Disease and Treatment, June 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)

Mentioned by

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3 tweeters
facebook
1 Facebook page

Citations

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5 Dimensions

Readers on

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27 Mendeley
Title
The social functional outcome of being naturalistically treated with paliperidone extended-release in patients with schizophrenia
Published in
Neuropsychiatric Disease and Treatment, June 2015
DOI 10.2147/ndt.s85891
Pubmed ID
Authors

Takashi Ohnishi, Ryoko Nakagawa, HIsanori kobayashi, Akihide Wakamatsu, Ai Tanimura, Kazuo Morita, Toshio Yamaoka, Hideo Usui, Yoshimasa Ogawa, Akiko Fujino, Kazutake Yoshizawa

Abstract

Social functioning is an important outcome for patients with schizophrenia. To evaluate the effects of paliperidone extended-release (PAL-ER) on social function, symptomatology, and safety in the routine clinical practice, we conducted a 1-year post-marketing surveillance study of PAL-ER. We also explored relationships between symptomatic improvement and socially functional outcome in patients with schizophrenia. Patients with an established diagnosis of schizophrenia were allowed flexible 3-12 mg/day dosing during the surveillance. Patients were assessed on social functioning using the Social and Occupational Functioning Assessment Scale (SOFAS) and on symptomatology using the Clinical Global Impression-Schizophrenia scale. All adverse events (AEs) were also collected. A total of 1,429 patients were enrolled in the surveillance study, of whom 1,405 were evaluable for safety and 1,142 were evaluable for efficacy. The treatment discontinuation rate for any reason during the observation period was 34.66%. Significant improvements were observed on both Social and Occupational Functioning Assessment Scale and Clinical Global Impression-Schizophrenia scale during the observation period. The percentage of patients with socially functional remission (SOFAS ≥61) also increased significantly. A significant association between early improvements in positive symptoms, sex, severity of negative symptoms at baseline, and socially functional remission was observed. A total of 33.52% of patients had AEs and 8.75% of patients had serious AEs. Despite the recommendation of monotherapy with PAL-ER, 65.84% of patients were given additional antipsychotics (polypharmacy). Post hoc comparisons of monotherapy versus polypharmacy revealed that the monotherapy group had better outcomes and fewer AEs than the polypharmacy treated group. The improvement in social functioning and the rate of socially functional remission did not differ between groups. PAL-ER treatment showed effective symptom control and improvement in social functioning. The data suggest that early response to antipsychotic treatment should be important for functional outcomes.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 26 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 33%
Other 5 19%
Student > Ph. D. Student 4 15%
Student > Bachelor 3 11%
Student > Master 2 7%
Other 4 15%
Readers by discipline Count As %
Psychology 7 26%
Medicine and Dentistry 5 19%
Unspecified 3 11%
Nursing and Health Professions 3 11%
Social Sciences 3 11%
Other 6 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2015.
All research outputs
#7,224,510
of 12,517,383 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,047
of 2,120 outputs
Outputs of similar age
#104,237
of 233,278 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#69
of 98 outputs
Altmetric has tracked 12,517,383 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,120 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,278 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.