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Identification of genetic variants in the TNF promoter associated with COPD secondary to tobacco smoking and its severity

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, June 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

twitter
6 tweeters

Citations

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10 Dimensions

Readers on

mendeley
23 Mendeley
Title
Identification of genetic variants in the TNF promoter associated with COPD secondary to tobacco smoking and its severity
Published in
International Journal of Chronic Obstructive Pulmonary Disease, June 2015
DOI 10.2147/copd.s83298
Pubmed ID
Authors

Ramcés Falfán-Valencia, Juan Manuel Reséndiz-Hernández, Raúl Sansores, Rafael de Jesús Hernández-Zenteno, Gilberto Vargas-Alarcón, Laura Colin-Barenque, Mónica Velázquez-Uncal, Angel Camarena, Alejandra Ramírez-Venegas

Abstract

Chronic obstructive pulmonary disease (COPD) is an inflammatory disease that arises in response to noxious particles or gases. Associations of genetic polymorphisms in TNF have been reported in Asians and Caucasians, but not in Mestizo populations. A case-control study was conducted in two stages: in the first stage, patients with COPD (COPD group, n=165) and smokers without disease (SNC group, n=165) were included and the TNF promoter sequence was determined using direct sequencing. In the second stage, the identified polymorphisms were validated by real-time polymerase chain reaction (PCR) in COPD (n=260) and SNC (n=506). In the first stage, 11 different sets of "contig" alignments were determined, of which contig 10 was found to be associated with susceptibility (P=5.0E-04, OR [odds ratio] =3.64) and contig 1 with Global Initiative for COPD (GOLD) greater grade (P=1.0E-02, OR =3.82). The single nucleotide polymorphisms found in this region were individually identified; the GA genotypes of rs1800629 (P=0.038, OR =2.07), rs56036015 (P=0.0082, OR =3.18), and rs361525 (P=1.0E-02, OR =4.220) were higher in the COPD group vs the SNC group; after second-stage validation, rs1800629 (P=6.00E-03, OR =2.26) and rs56036015 (P=1.10E-03, OR =2.54) are maintained. There are genetic variants in the TNF promoter associated with increased risk of COPD secondary to smoking and with a higher GOLD grade in the Mexican Mestizo population.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Canada 1 4%
Unknown 21 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 22%
Student > Master 4 17%
Student > Bachelor 4 17%
Student > Postgraduate 3 13%
Student > Ph. D. Student 3 13%
Other 3 13%
Unknown 1 4%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 30%
Agricultural and Biological Sciences 5 22%
Medicine and Dentistry 2 9%
Veterinary Science and Veterinary Medicine 1 4%
Environmental Science 1 4%
Other 3 13%
Unknown 4 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2015.
All research outputs
#4,166,923
of 14,326,345 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#597
of 1,758 outputs
Outputs of similar age
#66,913
of 232,290 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#20
of 81 outputs
Altmetric has tracked 14,326,345 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,758 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,290 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.