Title |
Animal models of polymicrobial pneumonia
|
---|---|
Published in |
Drug Design, Development and Therapy, June 2015
|
DOI | 10.2147/dddt.s70993 |
Pubmed ID | |
Authors |
Sami Hraiech, Laurent Papazian, Jean-Marc Rolain, Fabienne Bregeon |
Abstract |
Pneumonia is one of the leading causes of severe and occasionally life-threatening infections. The physiopathology of pneumonia has been extensively studied, providing information for the development of new treatments for this condition. In addition to in vitro research, animal models have been largely used in the field of pneumonia. Several models have been described and have provided a better understanding of pneumonia under different settings and with various pathogens. However, the concept of one pathogen leading to one infection has been challenged, and recent flu epidemics suggest that some pathogens exhibit highly virulent potential. Although "two hits" animal models have been used to study infectious diseases, few of these models have been described in pneumonia. Therefore the aims of this review were to provide an overview of the available literature in this field, to describe well-studied and uncommon pathogen associations, and to summarize the major insights obtained from this information. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
India | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 93 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 17% |
Researcher | 13 | 14% |
Student > Bachelor | 12 | 13% |
Student > Master | 10 | 11% |
Student > Postgraduate | 4 | 4% |
Other | 11 | 12% |
Unknown | 27 | 29% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 16 | 17% |
Agricultural and Biological Sciences | 16 | 17% |
Immunology and Microbiology | 14 | 15% |
Biochemistry, Genetics and Molecular Biology | 5 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
Other | 5 | 5% |
Unknown | 32 | 34% |