| Title |
Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options
|
|---|---|
| Published in |
Journal of Blood Medicine, July 2015
|
| DOI | 10.2147/jbm.s71319 |
| Pubmed ID | |
| Authors |
Tia Solh, Ashley Botsford, Melhem Solh |
| Abstract |
Glanzmann's thrombasthenia (GT) is a genetic platelet surface receptor disorder of GPIIb/IIIa (ITG αIIbβ3), either qualitative or quantitative, which results in faulty platelet aggregation and diminished clot retraction. Spontaneous mucocutaneous bleeding is common and can lead to fatal bleeding episodes. Control and prevention of bleeding among patients with GT is imperative, and remains challenging. Local measures, including anti-fibrinolytic therapy, with or without platelet transfusions, used to be the mainstay of therapy. However, in recent years the use of recombinant factor VIIa (rFVIIa) has increased significantly, with excellent response rates in treating and preventing hemorrhage among GT patients. Gene therapy and stem cell transplantation offer a potential cure of this disease, but both are costly and remain experimental at this point. This manuscript offers a comprehensive review of our understanding of GT and the available treatment options. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Unknown | 104 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 18 | 17% |
| Student > Ph. D. Student | 10 | 10% |
| Student > Master | 7 | 7% |
| Student > Postgraduate | 6 | 6% |
| Student > Doctoral Student | 5 | 5% |
| Other | 19 | 18% |
| Unknown | 40 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 34% |
| Biochemistry, Genetics and Molecular Biology | 11 | 10% |
| Agricultural and Biological Sciences | 5 | 5% |
| Immunology and Microbiology | 3 | 3% |
| Chemistry | 2 | 2% |
| Other | 5 | 5% |
| Unknown | 43 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2021.
All research outputs
#5,505,970
of 25,584,565 outputs
Outputs from Journal of Blood Medicine
#71
of 318 outputs
Outputs of similar age
#63,300
of 277,879 outputs
Outputs of similar age from Journal of Blood Medicine
#1
of 7 outputs
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