https://t.co/o0UjTSHxch "Patients who are unable to sense or appropriately respond to thirst stimulation should not take tolvaptan because this increases the risk of rapid correction of serum Na+."
3,626 followers
3,626 followers
https://t.co/o0UjTSHxch "It should not be administered in anuric patients due to expected lack of clinical benefit."
3,626 followers
https://t.co/o0UjTSHxch "Tolvaptan is contraindicated with the use of a strong CYP 3A inhibitor due to drug interaction." "It is also contraindicated in hypovolemic hyponatremia because it might precipitate hypotension and renal failure."
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Tolvaptan, hyponatremia, and heart failure https://t.co/o0UjTSHxch
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@askrenal @NephJC @nephrosingh Thiazides affect concentration and dilution, more likely to cause hypoNa, might avoid. Might prefer aldactone and loop over thiazides and loop but no data I'm aware of. Ideally i would use loop and tolvaptan. https://t.co/SWC