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Biodegradable double nanocapsule as a novel multifunctional carrier for drug delivery and cell imaging

Overview of attention for article published in International Journal of Nanomedicine, June 2015
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Mentioned by

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1 Facebook page

Citations

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13 Dimensions

Readers on

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32 Mendeley
Title
Biodegradable double nanocapsule as a novel multifunctional carrier for drug delivery and cell imaging
Published in
International Journal of Nanomedicine, June 2015
DOI 10.2147/ijn.s83731
Pubmed ID
Authors

Ailing Fu, Jing Wu, Enqi Zhang, Yingge Zhang, Kun Qian

Abstract

Highly-efficient delivery of macromolecules into cells for both imaging and therapy (theranostics) remains a challenge for the design of a delivery system. Here, we suggested a novel hybrid protein-lipid polymer nanocapsule as an effective and nontoxic drug delivery and imaging carrier. The biodegradable nanocapsules showed the typical double emulsion features, including fluorescently labeled bovine serum albumin shell, oil phase containing poly(lactic-co-glycolic acid) and linoleic acid, and inner aqueous phase. The nanocapsules were spherical in shape, with an average size of about 180 nm. Proteins packed into the inner aqueous phase of the nanocapsules could be delivered into cells with high efficiency, and the fluorescence of the fluorescently labeled bovine serum albumin could be used for tracing the protein migration and cellular location. Further studies suggested that the co-delivery of transcription factor p53 and lipophilic drug paclitaxel with the nanocapsules acted synergistically to induce Hela cell apoptosis, and the fluorescence of apoptotic cells was clearly observed under a fluorescence microscope. Such multifunctional delivery system would have great potential applications in drug delivery and theranostic fields.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 31 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 22%
Student > Doctoral Student 5 16%
Student > Bachelor 5 16%
Researcher 5 16%
Student > Master 5 16%
Other 5 16%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 6 19%
Agricultural and Biological Sciences 5 16%
Medicine and Dentistry 5 16%
Biochemistry, Genetics and Molecular Biology 4 13%
Materials Science 4 13%
Other 6 19%
Unknown 2 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2015.
All research outputs
#20,283,046
of 22,817,213 outputs
Outputs from International Journal of Nanomedicine
#3,325
of 3,816 outputs
Outputs of similar age
#223,415
of 267,474 outputs
Outputs of similar age from International Journal of Nanomedicine
#109
of 109 outputs
Altmetric has tracked 22,817,213 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,816 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,474 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.