| Title |
Altered blood oxygen level-dependent signal variability in chronic post-traumatic stress disorder during symptom provocation
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, July 2015
|
| DOI | 10.2147/ndt.s87332 |
| Pubmed ID | |
| Authors |
Jun Ke, Li Zhang, Rongfeng Qi, Qiang Xu, Weihui Li, Cailan Hou, Yuan Zhong, Zhiqiang Zhang, Zhong He, Lingjiang Li, Guangming Lu |
| Abstract |
Recent research suggests that variability in brain signal provides important information about brain function in health and disease. However, it is unknown whether blood oxygen level-dependent (BOLD) signal variability is altered in post-traumatic stress disorder (PTSD). We aimed to identify the BOLD signal variability changes of PTSD patients during symptom provocation and compare the brain patterns of BOLD signal variability with those of brain activation. Twelve PTSD patients and 14 age-matched controls, who all experienced a mining accident, underwent clinical assessment as well as fMRI scanning while viewing trauma-related and neutral pictures. BOLD signal variability and brain activation were respectively examined with standard deviation (SD) and general linear model analysis, and compared between the PTSD and control groups. Multiple regression analyses were conducted to explore the association between PTSD symptom severity and these two brain measures across all subjects as well as in the PTSD group. PTSD patients showed increased activation in the middle occipital gyrus compared with controls, and an inverse correlation was found between PTSD symptom severity and brain activation in the hippocampus and anterior cingulate cortex/medial prefrontal cortex. Brain variability analysis revealed increased SD in the insula, anterior cingulate cortex/medial prefrontal cortex, and vermis, and decreased SD in the parahippocapal gyrus, dorsolateral prefrontal cortex, somatosensory cortex, and striatum. Importantly, SD alterations in several regions were found in both traumatic and neutral conditions and were stratified by PTSD symptom severity. BOLD signal variability may be a reliable and sensitive biomarker of PTSD, and combining brain activation and brain variability analysis may provide complementary insight into the neural basis of this disorder. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Switzerland | 1 | 2% |
| Unknown | 48 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 26% |
| Student > Ph. D. Student | 8 | 16% |
| Student > Bachelor | 6 | 12% |
| Student > Doctoral Student | 4 | 8% |
| Student > Master | 3 | 6% |
| Other | 7 | 14% |
| Unknown | 9 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 13 | 26% |
| Neuroscience | 12 | 24% |
| Medicine and Dentistry | 8 | 16% |
| Unspecified | 3 | 6% |
| Biochemistry, Genetics and Molecular Biology | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 13 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2015.
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#16,048,009
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Outputs from Neuropsychiatric Disease and Treatment
#1,583
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#146,209
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Outputs of similar age from Neuropsychiatric Disease and Treatment
#50
of 91 outputs
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