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Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts

Overview of attention for article published in International Journal of Nanomedicine, July 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

twitter
3 tweeters
patent
1 patent
googleplus
1 Google+ user

Citations

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29 Dimensions

Readers on

mendeley
41 Mendeley
Title
Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts
Published in
International Journal of Nanomedicine, July 2015
DOI 10.2147/ijn.s81451
Pubmed ID
Authors

Rui Fang, Shupei Qiao, Yi Liu, Xiongbiao Chen, Bing Song, Qingyuan Meng, Xiaolu Hou, Weiming Tian

Abstract

Dedifferentiation and proliferation of endogenous cardiomyocytes in situ can effectively improve cardiac repair following myocardial infarction (MI). 6-Bromoindirubin-3-oxime (BIO) and insulin-like growth factor 1 (IGF-1) are two potent factors that promote cardiomyocyte survival and proliferation. However, their delivery for sustained release in MI-affected areas has proved to be challenging. In the current research, we present a study on the sustained co-delivery of BIO and IGF-1 in a hybrid hydrogel system to simulate endogenous cardiac repair in an MI rat model. Both BIO and IGF-1 were efficiently encapsulated in gelatin nanoparticles, which were later cross-linked with the oxidized alginate to form a novel hybrid hydrogel system. The in vivo results indicated that the hybrid system could enhance the proliferation of cardiomyocytes in situ and could promote revascularization around the MI sites, allowing improved cardiac function. Taken together, we concluded that the hybrid hydrogel system can co-deliver BIO and IGF-1 to areas of MI and thus improve cardiac function by promoting the proliferation of cardiomyocytes and revascularization.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 32%
Student > Master 10 24%
Student > Postgraduate 3 7%
Student > Bachelor 2 5%
Lecturer 1 2%
Other 4 10%
Unknown 8 20%
Readers by discipline Count As %
Engineering 8 20%
Agricultural and Biological Sciences 6 15%
Medicine and Dentistry 6 15%
Biochemistry, Genetics and Molecular Biology 5 12%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 5 12%
Unknown 9 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2020.
All research outputs
#4,801,042
of 19,486,479 outputs
Outputs from International Journal of Nanomedicine
#416
of 3,402 outputs
Outputs of similar age
#59,012
of 244,731 outputs
Outputs of similar age from International Journal of Nanomedicine
#6
of 142 outputs
Altmetric has tracked 19,486,479 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,402 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,731 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 142 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.