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A curcumin-loaded liquid crystal precursor mucoadhesive system for the treatment of vaginal candidiasis

Overview of attention for article published in International Journal of Nanomedicine, July 2015
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Mentioned by

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2 tweeters
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1 Facebook page

Citations

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47 Dimensions

Readers on

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76 Mendeley
Title
A curcumin-loaded liquid crystal precursor mucoadhesive system for the treatment of vaginal candidiasis
Published in
International Journal of Nanomedicine, July 2015
DOI 10.2147/ijn.s82385
Pubmed ID
Authors

Giovana Maria Fioramonti Calixto, Rafael Salmazi, Jéssica Bernegossi, Matheus Aparecido dos Santos Ramos, Taís Bauab, Marlus Chorilli

Abstract

Women often develop vaginal infections that are caused primarily by organisms of the genus Candida. The current treatments of vaginal candidiasis usually involve azole-based antifungals, though fungal resistance to these compounds has become prevalent. Therefore, much attention has been given to molecules with antifungal properties from natural sources, such as curcumin (CUR). However, CUR has poor solubility in aqueous solvents and poor oral bioavailability. This study attempted to overcome this problem by developing, characterizing, and evaluating the in vitro antifungal action of a CUR-loaded liquid crystal precursor mucoadhesive system (LCPM) for vaginal administration. A low-viscosity LCPM (F) consisting of 40% wt/wt polyoxpropylene-(5)-polyoxyethylene-(20)-cetyl alcohol, 50% wt/wt oleic acid, and 10% wt/wt chitosan dispersion at 0.5% with the addition of 16% poloxamer 407 was developed to take advantage of the lyotropic phase behavior of this formulation. Notably, F could transform into liquid crystal systems when diluted with artificial vaginal mucus at ratios of 1:3 and 1:1 (wt/wt), resulting in the formation of F30 and F100, respectively. Polarized light microscopy and rheological studies revealed that F behaved like an isotropic formulation, whereas F30 and F100 behaved like an anisotropic liquid crystalline system (LCS). Moreover, F30 and F100 presented higher mucoadhesion to porcine vaginal mucosa than F. The analysis of the in vitro activity against Candida albicans revealed that CUR-loaded F was more potent against standard and clinical strains compared with a CUR solution. Therefore, the vaginal administration of CUR-loaded LCPMs represents a promising platform for the treatment of vaginal candidiasis.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 4%
Unknown 73 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 22%
Student > Bachelor 14 18%
Student > Ph. D. Student 10 13%
Student > Doctoral Student 6 8%
Student > Postgraduate 4 5%
Other 7 9%
Unknown 18 24%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 23 30%
Medicine and Dentistry 13 17%
Immunology and Microbiology 5 7%
Materials Science 4 5%
Biochemistry, Genetics and Molecular Biology 4 5%
Other 9 12%
Unknown 18 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2016.
All research outputs
#4,535,673
of 8,482,675 outputs
Outputs from International Journal of Nanomedicine
#1,027
of 1,859 outputs
Outputs of similar age
#122,920
of 231,513 outputs
Outputs of similar age from International Journal of Nanomedicine
#101
of 142 outputs
Altmetric has tracked 8,482,675 research outputs across all sources so far. This one is in the 27th percentile – i.e., 27% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,859 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,513 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 142 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.