Title |
Bronchoscopic lung volume reduction by endobronchial valve in advanced emphysema: the first Asian report
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Published in |
International Journal of Chronic Obstructive Pulmonary Disease, July 2015
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DOI | 10.2147/copd.s85744 |
Pubmed ID | |
Authors |
Tai Sun Park, Yoonki Hong, Jae Seung Lee, Sang Young Oh, Sang Min Lee, Namkug Kim, Joon Beom Seo, Yeon-Mok Oh, Sang-Do Lee, Sei Won Lee |
Abstract |
Endobronchial valve (EBV) therapy is increasingly being seen as a therapeutic option for advanced emphysema, but its clinical utility in Asian populations, who may have different phenotypes to other ethnic populations, has not been assessed. This prospective open-label single-arm clinical trial examined the clinical efficacy and the safety of EBV in 43 consecutive patients (mean age 68.4±7.5, forced expiratory volume in 1 second [FEV1] 24.5%±10.7% predicted, residual volume 208.7%±47.9% predicted) with severe emphysema with complete fissure and no collateral ventilation in a tertiary referral hospital in Korea. Compared to baseline, the patients exhibited significant improvements 6 months after EBV therapy in terms of FEV1 (from 0.68±0.26 L to 0.92±0.40 L; P<0.001), 6-minute walk distance (from 233.5±114.8 m to 299.6±87.5 m; P=0.012), modified Medical Research Council dyspnea scale (from 3.7±0.6 to 2.4±1.2; P<0.001), and St George's Respiratory Questionnaire (from 65.59±13.07 to 53.76±11.40; P=0.028). Nine patients (20.9%) had a tuberculosis scar, but these scars did not affect target lobe volume reduction or pneumothorax frequency. Thirteen patients had adverse events, ten (23.3%) developed pneumothorax, which included one death due to tension pneumothorax. EBV therapy was as effective and safe in Korean patients as it has been shown to be in Western countries. ( ClinicalTrials.gov: NCT01869205). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 1% |
South Africa | 1 | 1% |
Unknown | 80 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 16 | 20% |
Researcher | 15 | 18% |
Student > Bachelor | 8 | 10% |
Other | 5 | 6% |
Librarian | 3 | 4% |
Other | 12 | 15% |
Unknown | 23 | 28% |
Readers by discipline | Count | As % |
---|---|---|
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Nursing and Health Professions | 7 | 9% |
Psychology | 4 | 5% |
Agricultural and Biological Sciences | 2 | 2% |
Computer Science | 2 | 2% |
Other | 8 | 10% |
Unknown | 28 | 34% |