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Animal models of obsessive–compulsive disorder: utility and limitations

Overview of attention for article published in Neuropsychiatric Disease and Treatment, August 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

blogs
2 blogs
twitter
3 tweeters
patent
9 patents
facebook
1 Facebook page

Citations

dimensions_citation
52 Dimensions

Readers on

mendeley
143 Mendeley
Title
Animal models of obsessive–compulsive disorder: utility and limitations
Published in
Neuropsychiatric Disease and Treatment, August 2015
DOI 10.2147/ndt.s62785
Pubmed ID
Authors

Pino Alonso, Clara López Solà, Eva Real, Cinto Segalàs, Jose M Menchon

Abstract

Obsessive-compulsive disorder (OCD) is a disabling and common neuropsychiatric condition of poorly known etiology. Many attempts have been made in the last few years to develop animal models of OCD with the aim of clarifying the genetic, neurochemical, and neuroanatomical basis of the disorder, as well as of developing novel pharmacological and neurosurgical treatments that may help to improve the prognosis of the illness. The latter goal is particularly important given that around 40% of patients with OCD do not respond to currently available therapies. This article summarizes strengths and limitations of the leading animal models of OCD including genetic, pharmacologically induced, behavioral manipulation-based, and neurodevelopmental models according to their face, construct, and predictive validity. On the basis of this evaluation, we discuss that currently labeled "animal models of OCD" should be regarded not as models of OCD but, rather, as animal models of different psychopathological processes, such as compulsivity, stereotypy, or perseverance, that are present not only in OCD but also in other psychiatric or neurological disorders. Animal models might constitute a challenging approach to study the neural and genetic mechanism of these phenomena from a trans-diagnostic perspective. Animal models are also of particular interest as tools for developing new therapeutic options for OCD, with the greatest convergence focusing on the glutamatergic system, the role of ovarian and related hormones, and the exploration of new potential targets for deep brain stimulation. Finally, future research on neurocognitive deficits associated with OCD through the use of analogous animal tasks could also provide a genuine opportunity to disentangle the complex etiology of the disorder.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 <1%
France 1 <1%
Brazil 1 <1%
Romania 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 137 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 26 18%
Student > Master 23 16%
Researcher 22 15%
Student > Ph. D. Student 18 13%
Other 7 5%
Other 23 16%
Unknown 24 17%
Readers by discipline Count As %
Neuroscience 34 24%
Agricultural and Biological Sciences 21 15%
Medicine and Dentistry 16 11%
Psychology 12 8%
Unspecified 6 4%
Other 22 15%
Unknown 32 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2022.
All research outputs
#1,803,891
of 22,739,983 outputs
Outputs from Neuropsychiatric Disease and Treatment
#221
of 2,977 outputs
Outputs of similar age
#25,010
of 264,140 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#6
of 92 outputs
Altmetric has tracked 22,739,983 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,977 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,140 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.