| Title |
Mutation EthAW21R confers co-resistance to protionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv
|
|---|---|
| Published in |
Infection and Drug Resistance, June 2018
|
| DOI | 10.2147/idr.s163965 |
| Pubmed ID | |
| Authors |
Julius Mugweru, Jianxiong Liu, Gaelle Makafe, Gift Chiwala, Bangxing Wang, Changwei Wang, Xinjie Li, Yaoju Tan, Wai Yew, Shouyong Tan, Tianyu Zhang |
| Abstract |
Ethionamide (ETA) and prothionamide (PRO) are interchangeably used in tuberculosis (TB) chemotherapy regimens. Subtle discrepancies between biochemical and genetic information on the modes of sensitivity and resistance of isoniazid (INH) and ETA warrants further studies. We report a new mutation - EthAW21R - in Mycobacterium bovis Bacillus Calmette-Guérin that corresponds with co-resistance to both PRO and ETA, which to the best of our knowledge has not been reported before. Our findings suggest that mutation EthAW21R could be used as a marker site for testing PRO and ETA cross-resistance. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Kenya | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 20% |
| Researcher | 3 | 20% |
| Student > Bachelor | 2 | 13% |
| Other | 1 | 7% |
| Lecturer | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 4 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 20% |
| Medicine and Dentistry | 2 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
| Environmental Science | 1 | 7% |
| Agricultural and Biological Sciences | 1 | 7% |
| Other | 3 | 20% |
| Unknown | 4 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2018.
All research outputs
#15,010,626
of 23,090,520 outputs
Outputs from Infection and Drug Resistance
#630
of 1,698 outputs
Outputs of similar age
#198,919
of 330,320 outputs
Outputs of similar age from Infection and Drug Resistance
#13
of 31 outputs
Altmetric has tracked 23,090,520 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,698 research outputs from this source. They receive a mean Attention Score of 3.8. This one has gotten more attention than average, scoring higher than 56% of its peers.
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We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.