| Title |
Involvement of the nuclear structural proteins in aging-related responses of human skin to the environmental stress
|
|---|---|
| Published in |
Clinical, Cosmetic and Investigational Dermatology, June 2018
|
| DOI | 10.2147/ccid.s163792 |
| Pubmed ID | |
| Authors |
Ewa Markiewicz, Olusola Clement Idowu |
| Abstract |
Human skin is a stratified endocrine organ with primary roles in protection against detrimental biochemical and biophysical factors in the environment. Environmental stress causes gradual accumulation of the macromolecular damage and clinical manifestations consistent with chronic inflammatory conditions and premature aging of the skin. Structural proteins of cell nucleus, the nuclear lamins and lamina-associated proteins, play an important role in the regulation of a number of signal transduction pathways associated with stress. The nuclear lamina proteins have been implicated in a number of degenerative disorders with frequent clinical manifestations of the skin conditions related to premature aging. Analysis of the molecular signatures in response of the skin to a range of damaging factors not only points at the likely involvement of the nuclear lamina in transmission of the signals between the environment and cell nucleus but also defines skin's sensitivity to stress, and therefore the capacities to counteract external damage in aging. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 16 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 19% |
| Student > Bachelor | 3 | 19% |
| Other | 2 | 13% |
| Student > Postgraduate | 2 | 13% |
| Student > Master | 2 | 13% |
| Other | 4 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 31% |
| Medicine and Dentistry | 4 | 25% |
| Biochemistry, Genetics and Molecular Biology | 3 | 19% |
| Immunology and Microbiology | 1 | 6% |
| Agricultural and Biological Sciences | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 2 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2020.
All research outputs
#15,315,638
of 25,604,262 outputs
Outputs from Clinical, Cosmetic and Investigational Dermatology
#459
of 916 outputs
Outputs of similar age
#182,423
of 343,402 outputs
Outputs of similar age from Clinical, Cosmetic and Investigational Dermatology
#8
of 13 outputs
Altmetric has tracked 25,604,262 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 916 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.2. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.