| Title |
Systematic literature review on patterns of pharmacological treatment and adherence among patients with bipolar disorder type I in the USA
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, June 2018
|
| DOI | 10.2147/ndt.s166730 |
| Pubmed ID | |
| Authors |
Mallik Greene, Luciano Paladini, Teresa Lemmer, Alexandra Piedade, Maelys Touya, Otavio Clark |
| Abstract |
Bipolar disorder type I (BD-I) is a chronic condition characterized by mania episodes followed by syndromic recovery periods, usually permeated by depressive symptoma-tology and recurring acute manic episodes. It requires long-term pharmacological treatment; thus, it is critical to understand the patterns of drug therapy use and medication compliance to better plan health care policies and needs. This systematic literature review aims to study these data among patients with BD-I in the USA, focusing on medications to treat mania. Articles published in the last 10 years to October 2016 were searched on MEDLINE and Embase. Studies on patterns of drug therapy, concordance of prescription with clinical practice guidelines, and adherence and persistence with pharmacological treatments for BD-I in the USA under observational conditions, with focus on treatments for mania, were selected. Treatment prevalence for BD-I is low in the USA, with the most current study showing a 46% 12-month rate. There is a lack of studies addressing the use of long-acting injectable (LAI) antipsychotics. Second-generation antipsychotics (SGAs) have been used by nearly all patients receiving oral antipsychotics since the 2000s. However, 30%-60% of individuals with BD do not receive appropriate treatment, and adherence to oral therapies is poor, with medication possession ratios ≥80% seen in only approximately 60% of patients. For persistence rates, results suggest that treatment duration is short for a condition with recommendation for at least 6 months of maintenance therapy. Literature indicates that LAI SGAs may be related to better adherence and persistence. There is a need for studies addressing specifically patterns of therapy and adherence to pharmacological treatment in BD-I patients in the USA to better understand the value of current standards, and an urgent need to improve the rates of adherence and persistence to BD-I pharmacotherapy and to increase the understanding of LAI SGAs' potential to address this issue. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 10% |
| Researcher | 7 | 10% |
| Other | 7 | 10% |
| Student > Bachelor | 6 | 9% |
| Student > Doctoral Student | 4 | 6% |
| Other | 9 | 13% |
| Unknown | 28 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 19% |
| Psychology | 7 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 9% |
| Nursing and Health Professions | 3 | 4% |
| Computer Science | 3 | 4% |
| Other | 8 | 12% |
| Unknown | 28 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2018.
All research outputs
#19,951,180
of 25,382,440 outputs
Outputs from Neuropsychiatric Disease and Treatment
#2,192
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Outputs of similar age
#251,834
of 342,877 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#50
of 78 outputs
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