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| Title |
An increased number of negative lymph nodes is associated with a higher immune response and longer survival in colon cancer patients
|
|---|---|
| Published in |
Cancer Management and Research, June 2018
|
| DOI | 10.2147/cmar.s160100 |
| Pubmed ID | |
| Authors |
Wen-Zhuo He, Qian-Kun Xie, Wan-Ming Hu, Peng-fei Kong, Lin Yang, Yuan-Zhong Yang, Chang Jiang, Chen-Xi Yin, Hui-Juan Qiu, Hui-Zhong Zhang, Bei Zhang, Liang-Ping Xia |
| Abstract |
The purpose of the present study was to examine the relationship among the number of negative lymph nodes (LNs), the local and systemic immune response, and survival in patients with colon cancer. One thousand one hundred and fifty-seven patients with colon cancer who underwent surgery at Sun Yat-sen University Cancer Center between 2009 and 2014 were included. We examined negative LNs in relation to the local and systemic immune response, including percentage carcinoma, neutrophil and lymphocyte infiltration, Crohn's-like reaction, neutrophil to lymphocyte ratio, platelets, and C-reactive protein (CRP). Disease-free survival and overall survival were also examined. We performed subgroup analysis based on the distribution of negative LNs. An increased number of negative LNs was associated with greater neutrophil invasion (p=0.001), more lymphocyte invasion (p=0.001), and more Crohn's-like reaction (p=0.001). No significant correlation was observed between negative LNs and the neutrophil to lymphocyte ratio. More than 12 negative LNs were associated with increased platelets and CRP levels. A higher number of negative LNs was independently associated with longer disease-free survival in stage I+II patients (p=0.004) and stage III patients (p=0.015), while negative LNs were also independent prognostic factors in stage IV patients (p=0.007). Our study suggests that negative LNs are indicators of the immune response and are associated with a better prognosis in patients with colon cancer. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 16% |
| Librarian | 1 | 5% |
| Other | 1 | 5% |
| Student > Bachelor | 1 | 5% |
| Student > Doctoral Student | 1 | 5% |
| Other | 2 | 11% |
| Unknown | 10 | 53% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 26% |
| Biochemistry, Genetics and Molecular Biology | 1 | 5% |
| Social Sciences | 1 | 5% |
| Agricultural and Biological Sciences | 1 | 5% |
| Unknown | 11 | 58% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2018.
All research outputs
#21,680,462
of 24,195,945 outputs
Outputs from Cancer Management and Research
#1,424
of 2,024 outputs
Outputs of similar age
#293,839
of 334,638 outputs
Outputs of similar age from Cancer Management and Research
#57
of 70 outputs
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So far Altmetric has tracked 2,024 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.