Title |
Progress toward overcoming hypoxia-induced resistance to solid tumor therapy
|
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Published in |
Cancer Management and Research, August 2015
|
DOI | 10.2147/cmar.s58285 |
Pubmed ID | |
Authors |
Sergey V Karakashev, Mauricio J Reginato |
Abstract |
Hypoxic tumors are associated with poor clinical outcome for multiple types of human cancer. This may be due, in part, to hypoxic cancer cells being resistant to anticancer therapy, including radiation therapy, chemotherapy, and targeted therapy. Hypoxia inducible factor 1, a major regulator of cellular response to hypoxia, regulates the expression of genes that are involved in multiple aspects of cancer biology, including cell survival, proliferation, metabolism, invasion, and angiogenesis. Here, we review multiple pathways regulated by hypoxia/hypoxia inducible factor 1 in cancer cells and discuss the latest advancements in overcoming hypoxia-mediated tumor resistance. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Poland | 2 | 2% |
India | 1 | <1% |
Unknown | 128 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 34 | 26% |
Student > Bachelor | 20 | 15% |
Researcher | 15 | 11% |
Student > Master | 11 | 8% |
Student > Postgraduate | 6 | 5% |
Other | 21 | 16% |
Unknown | 24 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 36 | 27% |
Agricultural and Biological Sciences | 24 | 18% |
Chemistry | 11 | 8% |
Medicine and Dentistry | 10 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Other | 14 | 11% |
Unknown | 31 | 24% |