| Title |
Relationship between linear and nonlinear dynamics of heart rate and impairment of lung function in COPD patients
|
|---|---|
| Published in |
International Journal of Chronic Obstructive Pulmonary Disease, August 2015
|
| DOI | 10.2147/copd.s81736 |
| Pubmed ID | |
| Authors |
Adriana Mazzuco, Wladimir Musetti Medeiros, Milena Pelosi Rizk Sperling, Aline Soares de Souza, Maria Clara Noman Alencar, Flávio Ferlin Arbex, José Alberto Neder, Ross Arena, Audrey Borghi-Silva |
| Abstract |
In chronic obstructive pulmonary disease (COPD), functional and structural impairment of lung function can negatively impact heart rate variability (HRV); however, it is unknown if static lung volumes and lung diffusion capacity negatively impacts HRV responses. We investigated whether impairment of static lung volumes and lung diffusion capacity could be related to HRV indices in patients with moderate to severe COPD. Sixteen sedentary males with COPD were enrolled in this study. Resting blood gases, static lung volumes, and lung diffusion capacity for carbon monoxide (DLCO) were measured. The RR interval (RRi) was registered in the supine, standing, and seated positions (10 minutes each) and during 4 minutes of a respiratory sinus arrhythmia maneuver (M-RSA). Delta changes (Δsupine-standing and Δsupine-M-RSA) of the standard deviation of normal RRi, low frequency (LF, normalized units [nu]) and high frequency (HF [nu]), SD1, SD2, alpha1, alpha2, and approximate entropy (ApEn) indices were calculated. HF, LF, SD1, SD2, and alpha1 deltas significantly correlated with forced expiratory volume in 1 second, DLCO, airway resistance, residual volume, inspiratory capacity/total lung capacity ratio, and residual volume/total lung capacity ratio. Significant and moderate associations were also observed between LF/HF ratio versus total gas volume (%), r=0.53; LF/HF ratio versus residual volume, %, r=0.52; and HF versus total gas volume (%), r=-0.53 (P<0.05). Linear regression analysis revealed that ΔRRi supine-M-RSA was independently related to DLCO (r=-0.77, r (2)=0.43, P<0.05). Responses of HRV indices were more prominent during M-RSA in moderate to severe COPD. Moreover, greater lung function impairment was related to poorer heart rate dynamics. Finally, impaired lung diffusion capacity was related to an altered parasympathetic response in these patients. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 95 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 16% |
| Student > Ph. D. Student | 11 | 11% |
| Student > Bachelor | 10 | 10% |
| Student > Master | 9 | 9% |
| Professor > Associate Professor | 6 | 6% |
| Other | 20 | 21% |
| Unknown | 25 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 28% |
| Nursing and Health Professions | 10 | 10% |
| Engineering | 9 | 9% |
| Agricultural and Biological Sciences | 6 | 6% |
| Psychology | 4 | 4% |
| Other | 10 | 10% |
| Unknown | 30 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2015.
All research outputs
#19,942,887
of 25,371,288 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#1,937
of 2,577 outputs
Outputs of similar age
#188,877
of 276,419 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#64
of 87 outputs
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