↓ Skip to main content

Dove Medical Press

Article Metrics

Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells

Overview of attention for article published in International Journal of Nanomedicine, August 2015
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

twitter
3 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
65 Dimensions

Readers on

mendeley
37 Mendeley
Title
Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells
Published in
International Journal of Nanomedicine, August 2015
DOI 10.2147/ijn.s89584
Pubmed ID
Authors

Jong Oh Kim, Tuan Hiep Tran, Thiruganesh Ramasamy, Ju Yeon Choi, Hanh Nguyen, Thanh Pham, Jee-Heon Jeong, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong

Abstract

The attachment of polyethylene glycol (PEG) increases the circulation time of drug-containing nanoparticles; however, this also negatively affects cellular uptake. To overcome this problem, unique lipid polymer hybrid (LPH) nanoparticles were developed with a pH-responsive PEG layer that detached prior to cell uptake. Docetaxel (DTX) was incorporated into the lipid core of the nanoparticles, which was then shielded with the pH-responsive block co-polymer polyethylene glycol-b-polyaspartic acid (PEG-b-PAsp) using a modified emulsion method. The optimized LPH nanoparticles were ~200 nm and had a narrow size distribution. Drug release from DTX-loaded LPH (DTX-LPH) nanoparticles was pH-sensitive, which is beneficial for tumor targeting. More importantly, DTX-LPH nanoparticles were able to effectively induce apoptosis in cancer cells. The negative surface charge and PEG shell of vehicle remarkably enhanced the blood circulation and physiological activity of DTX-LPH nanoparticles compared with that of free DTX. The nanoparticles were also found to reduce the size of tumors in tumor-bearing xenograft mice. The in vivo anticancer effect of DTX-LPH nanoparticles was further confirmed by the elevated levels of caspase-3 and poly ADP ribose polymerase found in the tumors after treatment. Thus, the results suggest that this novel LPH system could be an effective new treatment for cancer.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 24%
Student > Master 8 22%
Researcher 7 19%
Student > Bachelor 3 8%
Student > Postgraduate 2 5%
Other 5 14%
Unknown 3 8%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 10 27%
Medicine and Dentistry 6 16%
Agricultural and Biological Sciences 4 11%
Biochemistry, Genetics and Molecular Biology 4 11%
Chemistry 3 8%
Other 7 19%
Unknown 3 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2015.
All research outputs
#13,953,851
of 22,824,164 outputs
Outputs from International Journal of Nanomedicine
#1,550
of 3,816 outputs
Outputs of similar age
#131,084
of 264,261 outputs
Outputs of similar age from International Journal of Nanomedicine
#54
of 140 outputs
Altmetric has tracked 22,824,164 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,816 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,261 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 140 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.