| Title |
Synaptopodin-2 plays an important role in the metastasis of breast cancer via PI3K/Akt/mTOR pathway
|
|---|---|
| Published in |
Cancer Management and Research, June 2018
|
| DOI | 10.2147/cmar.s162670 |
| Pubmed ID | |
| Authors |
Erjie Xia, Xiaofen Zhou, Adheesh Bhandari, Xiaohua Zhang, Ouchen Wang |
| Abstract |
Synaptopodin 2 (SYNPO2) is a functioning protein. It has been detected in many malignancies. But the relation between SYNPO2 and breast cancer (BC) is unclear. In this study, we explored the expression and function of SYNPO2 in BC. We found that SYNPO2 gene in BC was downregulated at the transcriptional level in both validated and TCGA cohorts. The results revealed that age, lymph node metastasis, and clinical stage in the validated cohort were related to the expression of SYNPO2 negatively. Kaplan-Meier analysis showed that patients with lower SYNPO2 expression had a worse overall survival. We found that migration and invasion were promoted after knocking down SYNPO2 in MCF-7, MDA-MB-231, BT-549, and MDA-MB-468. Meanwhile, knockdown of SYNPO2 could enhance PI3K/AKT/mTOR signaling pathway, which may induce migration and invasion. Our findings reveal that SYNPO2 was associated with BC. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 2 | 18% |
| Student > Ph. D. Student | 2 | 18% |
| Student > Doctoral Student | 1 | 9% |
| Librarian | 1 | 9% |
| Student > Postgraduate | 1 | 9% |
| Other | 0 | 0% |
| Unknown | 4 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 2 | 18% |
| Veterinary Science and Veterinary Medicine | 1 | 9% |
| Biochemistry, Genetics and Molecular Biology | 1 | 9% |
| Chemical Engineering | 1 | 9% |
| Agricultural and Biological Sciences | 1 | 9% |
| Other | 1 | 9% |
| Unknown | 4 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2023.
All research outputs
#3,159,421
of 24,752,377 outputs
Outputs from Cancer Management and Research
#95
of 2,045 outputs
Outputs of similar age
#62,179
of 336,172 outputs
Outputs of similar age from Cancer Management and Research
#4
of 71 outputs
Altmetric has tracked 24,752,377 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,045 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,172 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.