| Title |
The histone demethylase PHF8 promotes prostate cancer cell growth by activating the oncomiR miR-125b
|
|---|---|
| Published in |
OncoTargets and therapy, August 2015
|
| DOI | 10.2147/ott.s85443 |
| Pubmed ID | |
| Authors |
Qiang Ma, Zhuo Chen, Guojin Jia, Xueqiang Lu, Xuefeng Xie, Wei Jin |
| Abstract |
Prostate cancer (PCa) is the most frequently diagnosed malignancy in men. However, the underlying mechanism is not fully understood. In this study, we aim to research the molecular mechanisms underlying the initiation and progression of PCa. Plant homeodomain finger protein 8 (PHF8) is upregulated in human PCa tissues and cell lines. PHF8 knockdown attenuates growth and cellular transformation of PCa cells. PHF8 depletion induces PCa cell apoptosis by activating proapoptotic proteins and inactivating antiapoptotic proteins. Furthermore, miR-125b is a target of PHF8, and miR-125b seems to be essential for the hyper proliferation of PCa cells in the presence of PHF8. In conclusion, we identify the histone demethylase PHF8 as an oncogenic protein in human PCa. These findings indicate PHF8 as a potential candidate for clinical intervention. |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 5% |
| Unknown | 20 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 24% |
| Researcher | 3 | 14% |
| Student > Bachelor | 2 | 10% |
| Student > Doctoral Student | 1 | 5% |
| Professor | 1 | 5% |
| Other | 5 | 24% |
| Unknown | 4 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 29% |
| Agricultural and Biological Sciences | 6 | 29% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 10% |
| Chemical Engineering | 1 | 5% |
| Unspecified | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 4 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2015.
All research outputs
#20,288,585
of 22,824,164 outputs
Outputs from OncoTargets and therapy
#1,969
of 2,933 outputs
Outputs of similar age
#220,874
of 264,261 outputs
Outputs of similar age from OncoTargets and therapy
#66
of 96 outputs
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