| Title |
Anterior cruciate ligament tears treated with percutaneous injection of autologous bone marrow nucleated cells: a case series
|
|---|---|
| Published in |
Journal of Pain Research, July 2015
|
| DOI | 10.2147/jpr.s86244 |
| Pubmed ID | |
| Authors |
Christopher J Centeno, John Pitts, Hasan Al-Sayegh, Michael D Freeman |
| Abstract |
This was a prospective case series designed to investigate treatment for anterior cruciate ligament (ACL) tears using an injection of autologous bone marrow concentrate. Consecutive adult patients presenting to a private outpatient interventional musculoskeletal and pain practice with knee pain, ACL laxity on exam, and magnetic resonance imaging (MRI) evidence of a grade 1, 2, or 3 ACL tears with less than 1 cm retraction were eligible for this study. Eligible patients were treated with an intraligamentous injection of autologous bone marrow concentrate, using fluoroscopic guidance. Pre- and postprocedural sagittal MRI images of the ACLs were analyzed using ImageJ software to objectively quantify changes between pre- and posttreatment scans. Five different types of measurement of ACL pixel intensity were examined as a proxy for ligament integrity. In addition pain visual analog scale (VAS) and Lower Extremity Functional Scale (LEFS) values were recorded at baseline and at 1 month, 3 months, 6 months, and annually postinjection. Objective outcomes measured were pre- to post-MRI measurement changes, as analyzed by the ImageJ software. Subjective outcomes measured were changes in the VAS and LEFS, and a self-rated percentage improvement. Seven of ten patients showed improvement in at least four of five objective measures of ACL integrity in their postprocedure MRIs. In the entire study group, the mean gray value, median, raw integrated density, and modal gray value all decreased toward low-signal ACLs (P=0.01, P=0.02, P=0.002, and P=0.08), indications of improved ligament integrity. Seven of ten patients responded to the self-rated metrics follow up. The mean VAS change was a decrease of 1.7 (P=0.25), the mean LEFS change was an increase of 23.3 (P=0.03), and mean reported improvement was 86.7%. Based on this small case series, autologous bone marrow concentrate shows promise in the treatment of grade 1, 2, and possibly grade 3 ACL tears without retraction. Further investigation using a controlled study design is warranted. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 113 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 17% |
| Student > Bachelor | 18 | 16% |
| Other | 10 | 9% |
| Student > Doctoral Student | 10 | 9% |
| Student > Postgraduate | 8 | 7% |
| Other | 16 | 14% |
| Unknown | 33 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 46 | 40% |
| Nursing and Health Professions | 11 | 10% |
| Engineering | 5 | 4% |
| Agricultural and Biological Sciences | 5 | 4% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Other | 8 | 7% |
| Unknown | 35 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2016.
All research outputs
#16,721,717
of 25,374,647 outputs
Outputs from Journal of Pain Research
#1,248
of 1,979 outputs
Outputs of similar age
#155,961
of 277,610 outputs
Outputs of similar age from Journal of Pain Research
#21
of 31 outputs
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