| Title |
Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease
|
|---|---|
| Published in |
International Journal of Nanomedicine, August 2015
|
| DOI | 10.2147/ijn.s87148 |
| Pubmed ID | |
| Authors |
Bruno Fonseca-Santos, Maria Palmira Daflon Gremião, Marlus Chorilli |
| Abstract |
Alzheimer's disease is a neurological disorder that results in cognitive and behavioral impairment. Conventional treatment strategies, such as acetylcholinesterase inhibitor drugs, often fail due to their poor solubility, lower bioavailability, and ineffective ability to cross the blood-brain barrier. Nanotechnological treatment methods, which involve the design, characterization, production, and application of nanoscale drug delivery systems, have been employed to optimize therapeutics. These nanotechnologies include polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, microemulsion, nanoemulsion, and liquid crystals. Each of these are promising tools for the delivery of therapeutic devices to the brain via various routes of administration, particularly the intranasal route. The objective of this study is to present a systematic review of nanotechnology-based drug delivery systems for the treatment of Alzheimer's disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 565 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | <1% |
| Germany | 1 | <1% |
| Kazakhstan | 1 | <1% |
| Austria | 1 | <1% |
| India | 1 | <1% |
| Unknown | 559 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 82 | 15% |
| Student > Bachelor | 80 | 14% |
| Student > Ph. D. Student | 70 | 12% |
| Researcher | 51 | 9% |
| Student > Doctoral Student | 30 | 5% |
| Other | 73 | 13% |
| Unknown | 179 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 110 | 19% |
| Biochemistry, Genetics and Molecular Biology | 52 | 9% |
| Chemistry | 44 | 8% |
| Agricultural and Biological Sciences | 34 | 6% |
| Medicine and Dentistry | 32 | 6% |
| Other | 83 | 15% |
| Unknown | 210 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2015.
All research outputs
#22,778,604
of 25,394,764 outputs
Outputs from International Journal of Nanomedicine
#3,599
of 4,122 outputs
Outputs of similar age
#236,387
of 276,518 outputs
Outputs of similar age from International Journal of Nanomedicine
#135
of 141 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,122 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,518 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 141 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.