| Title |
Role of Wnt/β-catenin signaling in hepatocellular carcinoma, pathogenesis, and clinical significance
|
|---|---|
| Published in |
Journal of Hepatocellular Carcinoma, June 2018
|
| DOI | 10.2147/jhc.s156701 |
| Pubmed ID | |
| Authors |
Ahmed M Khalaf, David Fuentes, Ali I Morshid, Mata R Burke, Ahmed O Kaseb, Manal Hassan, John D Hazle, Khaled M Elsayes |
| Abstract |
Hepatocellular carcinoma (HCC) is one of the most common primary hepatic malignancies and one of the fastest-growing causes of cancer-related mortality in the United States. The molecular basis of HCC carcinogenesis has not been clearly identified. Among the molecular signaling pathways implicated in the pathogenesis of HCC, the Wnt/β-catenin signaling pathway is one of the most frequently activated. A great effort is under way to clearly understand the role of this pathway in the pathogenesis of HCC and its role in the transition from chronic liver diseases, including viral hepatitis, to hepatocellular adenomas (HCAs) and HCCs and its targetability in novel therapies. In this article, we review the role of the β-catenin pathway in hepatocarcinogenesis and progression from chronic inflammation to HCC, the novel potential treatments targeting the pathway and its prognostic role in HCC patients, as well as the imaging features of HCC and their association with aberrant activation of the pathway. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 142 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 142 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 15% |
| Student > Bachelor | 22 | 15% |
| Researcher | 15 | 11% |
| Student > Master | 15 | 11% |
| Other | 6 | 4% |
| Other | 17 | 12% |
| Unknown | 45 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 47 | 33% |
| Medicine and Dentistry | 18 | 13% |
| Agricultural and Biological Sciences | 13 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Unspecified | 2 | 1% |
| Other | 10 | 7% |
| Unknown | 48 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2018.
All research outputs
#1,059,586
of 23,310,485 outputs
Outputs from Journal of Hepatocellular Carcinoma
#3
of 215 outputs
Outputs of similar age
#25,093
of 330,944 outputs
Outputs of similar age from Journal of Hepatocellular Carcinoma
#1
of 2 outputs
Altmetric has tracked 23,310,485 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 215 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,944 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them