Title |
LDL electronegativity index: a potential novel index for predicting cardiovascular disease
|
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Published in |
Vascular Health and Risk Management, August 2015
|
DOI | 10.2147/vhrm.s74697 |
Pubmed ID | |
Authors |
Ekaterina A Ivanova, Yuri V Bobryshev, Alexander N Orekhov |
Abstract |
High cardiovascular risk conditions are frequently associated with altered plasma lipoprotein profile, such as elevated low-density lipoprotein (LDL) and LDL cholesterol and decreased high-density lipoprotein. There is, however, accumulating evidence that specific subclasses of LDL may play an important role in cardiovascular disease development, and their relative concentration can be regarded as a more relevant risk factor. LDL particles undergo multiple modifications in plasma that can lead to the increase of their negative charge. The resulting electronegative LDL [LDL(-)] subfraction has been demonstrated to be especially atherogenic, and became a subject of numerous recent studies. In this review, we discuss the physicochemical properties of LDL(-), methods of its detection, atherogenic activity, and relevance of the LDL electronegativity index as a potential independent predictor of cardiovascular risk. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Practitioners (doctors, other healthcare professionals) | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Russia | 1 | 2% |
Unknown | 40 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 19% |
Student > Bachelor | 5 | 12% |
Student > Ph. D. Student | 4 | 10% |
Student > Doctoral Student | 4 | 10% |
Researcher | 3 | 7% |
Other | 12 | 29% |
Unknown | 6 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 26% |
Biochemistry, Genetics and Molecular Biology | 7 | 17% |
Agricultural and Biological Sciences | 6 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 10% |
Unspecified | 2 | 5% |
Other | 5 | 12% |
Unknown | 7 | 17% |