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Association between vitamin D receptor polymorphisms and osteoporosis in patients with COPD

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, September 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

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Citations

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59 Mendeley
Title
Association between vitamin D receptor polymorphisms and osteoporosis in patients with COPD
Published in
International Journal of Chronic Obstructive Pulmonary Disease, September 2015
DOI 10.2147/copd.s91576
Pubmed ID
Authors

Sei Won Kim, Jong Min Lee, Jick Hwan Ha, Hyeon Hui Kang, Chin Kook Rhee, Jin Woo Kim, Hwa Sik Moon, Ki Hyun Baek, Sang Haak Lee

Abstract

Patients with COPD are at an increased risk of osteoporosis. Although many studies have addressed the relationship between the vitamin D receptor (VDR) polymorphisms and bone health, this relationship has not been fully investigated in patients with COPD. In this study, we investigated the association of VDR polymorphisms with bone mineral density (BMD) and other clinical parameters in patients with COPD. In total, 200 patients with COPD were included in this study. The VDR polymorphisms rs1544410 (A/G-BsmI), rs7975232 (A/C-ApaI), rs731236 (C/T-TaqI), and rs10735810 (C/T-FokI) were determined by Sanger sequencing using blood DNA samples. BMD of the lumbar vertebra and the femoral neck was measured by dual-energy X-ray absorptiometry. Other clinical parameters were also evaluated. Haplotype and multivariate analyses were also performed. Sex, body mass index, steroid use, percentage of forced expiratory volume in 1 second (FEV1), alkaline phosphatase, and 25-hydroxyvitamin D significantly influenced the risk of osteoporosis. Patients with osteoporosis were more likely to carry the rs7975232 C allele compared to normal patients with BMD. Haplotypes GCT and GAT were related to osteoporosis. Patients without the haplotype GAT allele showed a significantly lower T-score at the femoral neck and an increased risk of osteoporosis (odds ratio [OR]= 2.78, 95% confidence interval [CI]= 1.20-6.48, P=0.018) compared with carriers in the dominant model. Genetic variations in VDR are significantly associated with osteoporosis among patients with COPD. Further studies are required to confirm the role of the VDR polymorphisms in osteoporosis among patients with COPD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 2%
Unknown 58 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 17%
Student > Master 10 17%
Student > Bachelor 7 12%
Student > Ph. D. Student 6 10%
Professor 3 5%
Other 11 19%
Unknown 12 20%
Readers by discipline Count As %
Medicine and Dentistry 13 22%
Biochemistry, Genetics and Molecular Biology 7 12%
Nursing and Health Professions 6 10%
Agricultural and Biological Sciences 6 10%
Sports and Recreations 2 3%
Other 8 14%
Unknown 17 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2015.
All research outputs
#7,205,295
of 25,374,647 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#824
of 2,577 outputs
Outputs of similar age
#77,920
of 276,791 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#33
of 85 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 2,577 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,791 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.