| Title |
Multiple effects of CD40–CD40L axis in immunity against infection and cancer
|
|---|---|
| Published in |
ImmunoTargets and Therapy, June 2018
|
| DOI | 10.2147/itt.s163614 |
| Pubmed ID | |
| Authors |
Anjuman Ara, Khawaja Ashfaque Ahmed, Jim Xiang |
| Abstract |
CD8+ cytotoxic T lymphocyte (CTL) protects against infection and cancer cells. Understanding the mechanisms involved in generation and maintenance of effective CTL responses is essential for improving disease therapy and vaccine protocols. During CTL responses, immune cells encounter several tightly regulated signaling pathways; therefore, in such a dynamic process, proper integration of critical signals is necessary to orchestrate an effective immune response. In this review, we have focused on CD40-CD40L interactions (a key signal) in the regulation of dendritic cell (DC)-T cell (CD4+ T and CD8+ T) cross-talk, rescuing CTL exhaustion, and converting DC tolerization. We have also highlighted the knowledge gap and future directions to design immunotherapies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 110 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 19% |
| Student > Ph. D. Student | 18 | 16% |
| Other | 9 | 8% |
| Student > Master | 9 | 8% |
| Student > Bachelor | 8 | 7% |
| Other | 15 | 14% |
| Unknown | 30 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 27 | 25% |
| Biochemistry, Genetics and Molecular Biology | 22 | 20% |
| Medicine and Dentistry | 11 | 10% |
| Agricultural and Biological Sciences | 10 | 9% |
| Engineering | 2 | 2% |
| Other | 7 | 6% |
| Unknown | 31 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2023.
All research outputs
#7,493,233
of 25,748,735 outputs
Outputs from ImmunoTargets and Therapy
#1
of 1 outputs
Outputs of similar age
#120,706
of 343,929 outputs
Outputs of similar age from ImmunoTargets and Therapy
#1
of 1 outputs
Altmetric has tracked 25,748,735 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1 research outputs from this source. They receive a mean Attention Score of 4.0. This one scored the same or higher as 0 of them.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them