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Cytotoxicity and physicochemical characterization of iron–manganese-doped sulfated zirconia nanoparticles

Overview of attention for article published in International Journal of Nanomedicine, September 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

twitter
5 tweeters

Citations

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17 Dimensions

Readers on

mendeley
22 Mendeley
Title
Cytotoxicity and physicochemical characterization of iron–manganese-doped sulfated zirconia nanoparticles
Published in
International Journal of Nanomedicine, September 2015
DOI 10.2147/ijn.s82586
Pubmed ID
Authors

Mohamed El Zowalaty, Mohamed Al-Fahdawi, Mothanna Al-Qubaisi, Fatah Alhassan, Rozita Rosli, Thomas Webster, Seïf-Eddine Naadja, Y Taufiq-Yap, Rasedee Abdullah

Abstract

Iron-manganese-doped sulfated zirconia nanoparticles with both Lewis and Brønsted acidic sites were prepared by a hydrothermal impregnation method followed by calcination at 650°C for 5 hours, and their cytotoxicity properties against cancer cell lines were determined. The characterization was carried out using X-ray diffraction, thermogravimetric analysis, Fourier transform infrared spectroscopy, Brauner-Emmett-Teller (BET) surface area measurements, X-ray fluorescence, X-ray photoelectron spectroscopy, zeta size potential, and transmission electron microscopy (TEM). The cytotoxicity of iron-manganese-doped sulfated zirconia nanoparticles was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays against three human cancer cell lines (breast cancer MDA-MB231 cells, colon carcinoma HT29 cells, and hepatocellular carcinoma HepG2 cells) and two normal human cell lines (normal hepatocyte Chang cells and normal human umbilical vein endothelial cells [HUVECs]). The results suggest for the first time that iron-manganese-doped sulfated zirconia nanoparticles are cytotoxic to MDA-MB231 and HepG2 cancer cells but have less toxicity to HT29 and normal cells at concentrations from 7.8 μg/mL to 500 μg/mL. The morphology of the treated cells was also studied, and the results supported those from the cytotoxicity study in that the nanoparticle-treated HepG2 and MDA-MB231 cells had more dramatic changes in cell morphology than the HT29 cells. In this manner, this study provides the first evidence that iron-manganese-doped sulfated zirconia nanoparticles should be further studied for a wide range of cancer applications without detrimental effects on healthy cell functions.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 23%
Student > Ph. D. Student 4 18%
Other 3 14%
Student > Bachelor 2 9%
Student > Doctoral Student 2 9%
Other 2 9%
Unknown 4 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 23%
Materials Science 2 9%
Veterinary Science and Veterinary Medicine 1 5%
Unspecified 1 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Other 6 27%
Unknown 6 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2015.
All research outputs
#2,359,341
of 6,422,619 outputs
Outputs from International Journal of Nanomedicine
#310
of 1,544 outputs
Outputs of similar age
#75,935
of 195,844 outputs
Outputs of similar age from International Journal of Nanomedicine
#30
of 145 outputs
Altmetric has tracked 6,422,619 research outputs across all sources so far. This one has received more attention than most of these and is in the 61st percentile.
So far Altmetric has tracked 1,544 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,844 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 145 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.