| Title |
Risk factors for gastric intraepithelial neoplasia in Chinese adults: a case–control study
|
|---|---|
| Published in |
Cancer Management and Research, August 2018
|
| DOI | 10.2147/cmar.s166472 |
| Pubmed ID | |
| Authors |
Yanqiu Yu, Cheng Fang, Chunyan Peng, Shanshan Shen, Guifang Xu, Qi Sun, Lin Li, Chuan Su, Xiaoping Zou |
| Abstract |
Gastric carcinoma (GC) is the third most frequent malignancy and the second most common cancer-related cause of death cause worldwide. Gastric intraepithelial neoplasia (GIN) is a well-documented precancerous lesion of GC. In this case-control study, we comprehensively explored the clinical and pathological characteristics of GIN, with the aim to identify its potential risk factors. A total of 630 consecutive patients who underwent endoscopic submucosal dissection or mucosal resection for GIN were initially included. The detailed characteristics of all eligible patients and well-matched healthy controls were recorded and analyzed. Both univariate and multivariate logistic regression analyses were performed and presented with odds ratio (OR) and 95% confidential interval (CI), with additional subgroup analyses based on lesion location. A total of 485 GIN-eligible patients were selected, among which 156 had proximal GIN. After follow-up, 434 patients with GIN and 310 age- and gender-matched healthy controls were included in the comparative analyses. Family cancer history (FCH); alcohol abuse; tobacco abuse; intake of high sodium, preserved food, spicy food, and less fruit; Helicobacter pylori (Hp) infection; and atrophic gastritis with intestinal metaplasia were more frequent in GIN patients. Thus, FCH (OR =3.485, 95% CI: 2.031-5.981), high sodium intake (OR =2.830, 95% CI: 1.645-4.868), less fruit intake (OR =4.082, 95% CI: 2.515-6.625), Hp infection (OR =2.307, 95% CI: 1.417-3.755), and atrophic gastritis with intestinal metaplasia (OR =15.070, 95% CI: 8.999-25.237) were independent risk factors for GIN. Further subgroup analyses demonstrated that the specific independent risk factor for proximal GIN was age (OR =2.001, 95% CI: 1.003-3.994), whereas that for distal GIN was intake of high sodium (OR =3.467, 95% CI: 1.896-6.338). This study reported a comprehensive overview of the clinical and pathological characteristics of GIN. FCH, high sodium intake, less fruit intake, Hp infection, and atrophic gastritis were identified as the independent risk factors for GIN. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 20 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor > Associate Professor | 3 | 15% |
| Student > Bachelor | 2 | 10% |
| Student > Master | 2 | 10% |
| Student > Doctoral Student | 2 | 10% |
| Lecturer > Senior Lecturer | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 8 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 30% |
| Nursing and Health Professions | 3 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Immunology and Microbiology | 1 | 5% |
| Chemical Engineering | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 8 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 August 2018.
All research outputs
#17,292,294
of 25,385,509 outputs
Outputs from Cancer Management and Research
#792
of 2,074 outputs
Outputs of similar age
#220,369
of 341,886 outputs
Outputs of similar age from Cancer Management and Research
#36
of 86 outputs
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