Title |
Co-production of MCR-1 and NDM-5 in Escherichia coli isolated from a colonization case of inpatient
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Published in |
Infection and Drug Resistance, August 2018
|
DOI | 10.2147/idr.s171164 |
Pubmed ID | |
Authors |
Siyuan Feng, Cong Shen, Hongtao Chen, Xiaobin Zheng, Yong Xia, Lan-Lan Zhong, Xi Huang, Xinwei Wu, Guo-Bao Tian |
Abstract |
Colistin is increasingly used as an antibiotic of last resort for treating carbapenem-resistant Enterobacteriaceae. Mobile colistin resistance gene mcr-1 has been increasingly reported in Enterobacteriaceae around the world. Of particular concern is the spread of mcr-1 into carbapenemase-producing Enterobacteriaceae, which results in highly drug-resistant strains that are potentially untreatable. Notably, such mcr-1-carrying isolates harboring carbapenemase genes have been reported in animals and patients with infection. Here, we report an Escherichia coli strain carrying co-transferable mcr-1-harboring IncX4 and blaNDM-5-harboring IncX3 plasmids, which was recovered in the context of fecal colonization. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 36% |
Student > Bachelor | 5 | 20% |
Student > Postgraduate | 2 | 8% |
Student > Ph. D. Student | 1 | 4% |
Other | 1 | 4% |
Other | 2 | 8% |
Unknown | 5 | 20% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 4 | 16% |
Veterinary Science and Veterinary Medicine | 3 | 12% |
Medicine and Dentistry | 3 | 12% |
Immunology and Microbiology | 3 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
Other | 4 | 16% |
Unknown | 6 | 24% |