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The interaction of sterically stabilized magnetic nanoparticles with fresh human red blood cells

Overview of attention for article published in International Journal of Nanomedicine, October 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

Mentioned by

twitter
3 tweeters
facebook
1 Facebook page

Citations

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13 Dimensions

Readers on

mendeley
14 Mendeley
Title
The interaction of sterically stabilized magnetic nanoparticles with fresh human red blood cells
Published in
International Journal of Nanomedicine, October 2015
DOI 10.2147/ijn.s93225
Pubmed ID
Authors

Brian Hawkett, Binh Pham, Nirmesh Jain, Philip Kuchel, Bogdan Chapman, Stephanie Bickley, Steve Jones

Abstract

Sterically stabilized superparamagnetic iron oxide nanoparticles (SPIONs) were incubated with fresh human erythrocytes (red blood cells [RBCs]) to explore their potential application as magnetic resonance imaging contrast agents. The chemical shift and linewidth of (133)Cs(+) resonances from inside and outside the RBCs in (133)Cs nuclear magnetic resonance spectra were monitored as a function of time. Thus, we investigated whether SPIONs of two different core sizes and with three different types of polymeric stabilizers entered metabolically active RBCs, consuming glucose at 37°C. The SPIONs broadened the extracellular (133)Cs(+) nuclear magnetic resonance, and brought about a small change in its chemical shift to a higher frequency; while the intracellular resonance remained unchanged in both amplitude and chemical shift. This situation pertained over incubation times of up to 90 minutes. If the SPIONs had entered the RBCs, the intracellular resonance would have become broader and possibly even shifted. Therefore, we concluded that our SPIONs did not enter the RBCs. In addition, the T 2 relaxivity of the small and large particles was 368 and 953 mM(-1) s(-1), respectively (three and nine times that of the most effective commercially available samples). This suggests that these new SPIONs will provide a superior performance to any others reported thus far as magnetic resonance imaging contrast agents.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 21%
Researcher 3 21%
Professor 2 14%
Student > Master 2 14%
Unspecified 1 7%
Other 2 14%
Unknown 1 7%
Readers by discipline Count As %
Chemistry 5 36%
Agricultural and Biological Sciences 2 14%
Biochemistry, Genetics and Molecular Biology 2 14%
Unspecified 1 7%
Immunology and Microbiology 1 7%
Other 3 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2015.
All research outputs
#6,349,738
of 11,338,470 outputs
Outputs from International Journal of Nanomedicine
#746
of 2,260 outputs
Outputs of similar age
#105,194
of 251,883 outputs
Outputs of similar age from International Journal of Nanomedicine
#46
of 123 outputs
Altmetric has tracked 11,338,470 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,260 research outputs from this source. They receive a mean Attention Score of 3.0. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,883 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.