| Title |
B7-H3 promotes metastasis, proliferation, and epithelial-mesenchymal transition in lung adenocarcinoma
|
|---|---|
| Published in |
OncoTargets and therapy, August 2018
|
| DOI | 10.2147/ott.s169811 |
| Pubmed ID | |
| Authors |
Ting-Ting Yu, Tao Zhang, Xi Lu, Ruo-Zheng Wang |
| Abstract |
Lung adenocarcinoma is the most common pathological type of lung cancer. However, the mechanisms underlying its development are still poorly understood. B7-H3 was discovered as a new member of the B7 costimulatory family. We detected the expression status of B7-H3 protein in lung adenocarcinoma tissues, and evaluated the relationship of B7-H3 expression and patients' prognosis. Then, we silenced its expression in A549 cells by transient siRNA transfection to ascertain the function of B7-H3 in lung adenocarcinoma cells. Western blotting was used to detect the expression of epithelial-mesenchymal transition (EMT) related proteins. We found that B7-H3 overexpressed in lung adenocarcinoma. It is correlated with lymph node metastasis, distant metastasis, and disease stage. The Cox regression analysis showed that B7-H3 might serve as an independent prognostic marker of lung adenocarcinoma. We also found that B7-H3 promoted proliferation, invasion and migration of A549 cells in vitro. B7-H3 also could promote EMT progression by regulating EMT-related molecules. B7-H3 is a potential target for the treatment of lung adenocarcinoma. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 2 | 13% |
| Other | 1 | 7% |
| Student > Doctoral Student | 1 | 7% |
| Unspecified | 1 | 7% |
| Student > Ph. D. Student | 1 | 7% |
| Other | 3 | 20% |
| Unknown | 6 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 13% |
| Medicine and Dentistry | 2 | 13% |
| Unspecified | 1 | 7% |
| Immunology and Microbiology | 1 | 7% |
| Nursing and Health Professions | 1 | 7% |
| Other | 2 | 13% |
| Unknown | 6 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2018.
All research outputs
#22,767,715
of 25,385,509 outputs
Outputs from OncoTargets and therapy
#2,080
of 3,016 outputs
Outputs of similar age
#299,007
of 341,886 outputs
Outputs of similar age from OncoTargets and therapy
#75
of 114 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,016 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,886 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 114 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.