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Association study of sepiapterin reductase gene promoter polymorphisms with schizophrenia in a Han Chinese population

Overview of attention for article published in Neuropsychiatric Disease and Treatment, October 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Mentioned by

twitter
4 tweeters
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

dimensions_citation
2 Dimensions

Readers on

mendeley
9 Mendeley
Title
Association study of sepiapterin reductase gene promoter polymorphisms with schizophrenia in a Han Chinese population
Published in
Neuropsychiatric Disease and Treatment, October 2015
DOI 10.2147/ndt.s92986
Pubmed ID
Authors

Jiawu Fu, Guoda Ma, Hui Mai, Xudong Luo, Jingwen Yin, Qing Chen, Zhixiong Lin, Hua Tao, You Li, Lili Cui, Zheng Li, Bin Zhao, Keshen Li, Juda Lin

Abstract

Sepiapterin reductase participates in the biosynthesis of tetrahydrobiopterin, which plays very important roles in the pathogenesis of schizophrenia via dysregulation of neurotransmitter systems. Here, two single nucleotide polymorphisms (rs1876487 and rs2421095) in the promoter region of SPR were genotyped in 941 schizophrenic patients and 944 controls in a Han Chinese population using the SNaPshot technique. No significant differences were found in the distribution of alleles or genotypes of the two single nucleotide polymorphisms (SNPs) between schizophrenic patients and controls (all P>0.05). Likewise, no haplotype was found to be associated with schizophrenia. However, sex-stratified analysis revealed that the frequencies of the A allele of rs1876487 and the A-A (rs2421095-rs1876487) haplotype were all significantly different between schizophrenia and controls in females (P=0.040 and P=0.033, respectively), but not in males. Additionally, luciferase reporter gene assays revealed that the A-A haplotype had significantly higher SPR transcriptional activity compared with the A-C haplotype in SH-SY5Y cells. Our data indicate that the two SNPs do not influence the risk of schizophrenia when using the total sample, but the A allele of rs1876487 and the A-A haplotype may contribute to protective roles for schizophrenia in females.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 33%
Professor 2 22%
Researcher 2 22%
Student > Ph. D. Student 1 11%
Unknown 1 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 1 11%
Psychology 1 11%
Decision Sciences 1 11%
Unknown 6 67%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2015.
All research outputs
#12,744,018
of 22,831,537 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,141
of 2,986 outputs
Outputs of similar age
#119,030
of 274,921 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#35
of 77 outputs
Altmetric has tracked 22,831,537 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,986 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,921 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.