| Title |
Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems
|
|---|---|
| Published in |
International Journal of Nanomedicine, October 2015
|
| DOI | 10.2147/ijn.s91864 |
| Pubmed ID | |
| Authors |
Jichuan Qiu, Ruibin Zhang, Jianhua Li, Yuanhua Sang, Wei Tang, Pilar Rivera Gil, Hong Liu |
| Abstract |
Graphene quantum dots (GQDs) were rationally fabricated as a traceable drug delivery system for the targeted, pH-sensitive delivery of a chemotherapeutic drug into cancer cells. The GQDs served as fluorescent carriers for a well-known anticancer drug, doxorubicin (Dox). The whole system has the capacity for simultaneous tracking of the carrier and of drug release. Dox release is triggered upon acidification of the intracellular vesicles, where the carriers are located after their uptake by cancer cells. Further functionalization of the loaded carriers with targeting moieties such as arginine-glycine-aspartic acid (RGD) peptides enhanced their uptake by cancer cells. DU-145 and PC-3 human prostate cancer cell lines were used to evaluate the anticancer ability of Dox-loaded RGD-modified GQDs (Dox-RGD-GQDs). The results demonstrated the feasibility of using GQDs as traceable drug delivery systems with the ability for the pH-triggered delivery of drugs into target cells. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 50% |
| Canada | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 2 | 1% |
| Unknown | 133 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 21% |
| Student > Master | 22 | 16% |
| Student > Bachelor | 15 | 11% |
| Student > Doctoral Student | 9 | 7% |
| Researcher | 8 | 6% |
| Other | 18 | 13% |
| Unknown | 34 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 16 | 12% |
| Biochemistry, Genetics and Molecular Biology | 14 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 10% |
| Materials Science | 13 | 10% |
| Engineering | 12 | 9% |
| Other | 29 | 21% |
| Unknown | 37 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2023.
All research outputs
#17,432,668
of 25,576,275 outputs
Outputs from International Journal of Nanomedicine
#2,488
of 4,142 outputs
Outputs of similar age
#172,199
of 287,373 outputs
Outputs of similar age from International Journal of Nanomedicine
#114
of 133 outputs
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So far Altmetric has tracked 4,142 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
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We're also able to compare this research output to 133 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.