| Title |
Epidemiology of and risk factors for infection with extended-spectrum β-lactamase-producing carbapenem-resistant Enterobacteriaceae: results of a double case–control study
|
|---|---|
| Published in |
Infection and Drug Resistance, August 2018
|
| DOI | 10.2147/idr.s173456 |
| Pubmed ID | |
| Authors |
Xiaolang Tian, Shan Sun, Xiaojiong Jia, Hua Zou, Shuang Li, Liping Zhang |
| Abstract |
Carbapenem-resistant Enterobacteriaceae (CRE) have been increasingly reported worldwide and pose a serious public threat, but the clinical significance of extended-spectrum β-lactamase (ESBL) production in CRE is not well established. A retrospective case-case-control study was conducted to identify the clinical characteristics of patients with ESBL-CRE. The susceptibility of isolates obtained from these patients was assessed. The detection of ESBL and carbapenemase-related genes was performed by PCR methods. Predictors of 30-day mortality in patients with ESBL-CRE infection were also identified in our study. A total of 149 patients with CRE infection caused by Enterobacter cloacae (n=74), Escherichia coli (n=38), and Klebsiella pneumoniae (n=37) were identified in Chongqing, Southwestern China, between January 2011 and December 2014. Of the 35 isolates detected with carbapenemase-related genes, 16 isolates had New Delhi metallo-β-lactamase (NDM), nine isolates had K. pneumoniae carbapenemase (KPC), seven isolates had imipenemase (IMP), and four isolates had oxacillinase (OXA)-1. One strain of enterobacter cloacae carried both NDM-1 and IMP-8 genes. ESBL isolates included the genes CTX-M (72/149), SHV (64/149), and TEM (54/149). All ESBL-CRE isolates exhibited ertapenem resistance, and the rate of cephalosporin resistance was relatively high in general. Independent risk factors for infection with ESBL-CRE included previous exposure to β-lactam antibiotics, transfer from another hospital, and some underlying diseases. In addition, solid tumors, hypoalbuminemia, and central venous catheters were independent predictors of mortality in patients with ESBL-CRE infection. Physicians should understand the peculiar predictors for the identification of these organisms among high-risk patients. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 58 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 19% |
| Student > Bachelor | 7 | 12% |
| Other | 4 | 7% |
| Researcher | 4 | 7% |
| Student > Ph. D. Student | 3 | 5% |
| Other | 5 | 9% |
| Unknown | 24 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 12% |
| Immunology and Microbiology | 5 | 9% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Veterinary Science and Veterinary Medicine | 2 | 3% |
| Other | 5 | 9% |
| Unknown | 25 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2019.
All research outputs
#7,106,528
of 24,701,594 outputs
Outputs from Infection and Drug Resistance
#274
of 1,975 outputs
Outputs of similar age
#115,785
of 335,829 outputs
Outputs of similar age from Infection and Drug Resistance
#13
of 57 outputs
Altmetric has tracked 24,701,594 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,975 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,829 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.