| Title |
Effect of opioid-substitution therapy and mental health counseling on HIV risk among hepatitis C-infected individuals
|
|---|---|
| Published in |
Clinical Epidemiology, August 2018
|
| DOI | 10.2147/clep.s173449 |
| Pubmed ID | |
| Authors |
Zahid A Butt, Nabin Shrestha, Dionne Gesink, Michelle Murti, Jane A Buxton, Mark Gilbert, Robert F Balshaw, Stanley Wong, Margot Kuo, Jason Wong, Amanda Yu, Maria Alvarez, Hasina Samji, David Roth, Theodora Consolacion, Mark W Hull, Gina Ogilvie, Mark W Tyndall, Mel Krajden, Naveed Z Janjua |
| Abstract |
Understanding differences in HIV incidence among people living with hepatitis C virus (HCV) can help inform strategies to prevent HIV infection. We estimated the time to HIV diagnosis among HCV-positive individuals and evaluated factors that could affect HIV-infection risk in this population. The British Columbia Hepatitis Testers Cohort includes all BC residents (~1.5 million: about a third of all residents) tested for HCV and HIV from 1990 to 2013 and is linked to administrative health care and mortality data. All HCV-positive and HIV-negative individuals were followed to measure time to HIV acquisition (positive test) and identify factors associated with HIV acquisition. Adjusted HRs (aHRs) were estimated using Cox proportional-hazard regression. Of 36,077 HCV-positive individuals, 2,169 (6%) acquired HIV over 266,883 years of follow-up (overall incidence of 8.1 per 1,000 person years). Overall median (IQR) time to HIV infection was 3.87 (6.06) years. In Cox regression, injection-drug use (aHR 1.47, 95% CI 1.33-1.63), HBV infection (aHR 1.34, 95% CI 1.16-1.55), and being a man who has sex with men (aHR 2.78, 95% CI 2.14-3.61) were associated with higher risk of HIV infection. Opioid-substitution therapy (OST) (aHR 0.59, 95% CI 0.52-0.67) and mental health counseling (aHR 0.48, 95% CI 0.43-0.53) were associated with lower risk of HIV infection. Injection-drug use, HBV coinfection, and being a man who has sex with men were associated with increased HIV risk and engagement in OST and mental health counseling were associated with reduced HIV risk among HCV-positive individuals. Improving access to OST and mental health services could prevent transmission of HIV and other blood-borne infections, especially in settings where access is limited. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 3 | 38% |
| United States | 2 | 25% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 63% |
| Scientists | 3 | 38% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 13% |
| Student > Bachelor | 6 | 12% |
| Student > Master | 6 | 12% |
| Student > Ph. D. Student | 3 | 6% |
| Student > Doctoral Student | 2 | 4% |
| Other | 7 | 13% |
| Unknown | 21 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 19% |
| Nursing and Health Professions | 6 | 12% |
| Psychology | 4 | 8% |
| Immunology and Microbiology | 3 | 6% |
| Business, Management and Accounting | 1 | 2% |
| Other | 5 | 10% |
| Unknown | 23 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2019.
All research outputs
#5,581,125
of 23,001,641 outputs
Outputs from Clinical Epidemiology
#208
of 727 outputs
Outputs of similar age
#95,530
of 330,801 outputs
Outputs of similar age from Clinical Epidemiology
#10
of 34 outputs
Altmetric has tracked 23,001,641 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 727 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.4. This one has gotten more attention than average, scoring higher than 71% of its peers.
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We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.