Title |
Homeostatic and pathogenic extramedullary hematopoiesis
|
---|---|
Published in |
Journal of Blood Medicine, March 2010
|
DOI | 10.2147/jbm.s7224 |
Pubmed ID | |
Authors |
Chang H Kim |
Abstract |
Extramedullary hematopoiesis (EH) is defined as hematopoiesis occurring in organs outside of the bone marrow; it occurs in diverse conditions, including fetal development, normal immune responses, and pathological circumstances. During fetal development, before formation of mature marrow, EH occurs in the yolk sac, fetal liver, and spleen. EH also occurs during active immune responses to pathogens. Most frequently, this response occurs in the spleen and liver for the production of antigen-presenting cells and phagocytes. EH also occurs when the marrow becomes inhabitable for stem and progenitor cells in certain pathological conditions, including myelofibrosis, where marrow cells are replaced with collagenous connective tissue fibers. Thus, EH occurs either actively or passively in response to diverse changes in the hematopoietic environment. This article reviews the key features and regulators of the major types of EH. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Central African Republic | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | <1% |
Mexico | 1 | <1% |
Brazil | 1 | <1% |
China | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 279 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 63 | 22% |
Student > Master | 39 | 14% |
Student > Bachelor | 35 | 12% |
Researcher | 26 | 9% |
Student > Doctoral Student | 18 | 6% |
Other | 39 | 14% |
Unknown | 65 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 69 | 24% |
Agricultural and Biological Sciences | 50 | 18% |
Biochemistry, Genetics and Molecular Biology | 47 | 16% |
Immunology and Microbiology | 17 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 2% |
Other | 19 | 7% |
Unknown | 77 | 27% |