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Advanced basal cell carcinoma, the hedgehog pathway, and treatment options – role of smoothened inhibitors

Overview of attention for article published in Biologics: Targets & Therapy, November 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

policy
1 policy source
twitter
1 tweeter

Citations

dimensions_citation
35 Dimensions

Readers on

mendeley
82 Mendeley
Title
Advanced basal cell carcinoma, the hedgehog pathway, and treatment options – role of smoothened inhibitors
Published in
Biologics: Targets & Therapy, November 2015
DOI 10.2147/btt.s54179
Pubmed ID
Authors

Leslie Fecher, William Sharfman

Abstract

Cutaneous basal cell carcinoma (BCC) is the most common human cancer and its incidence is rising worldwide. Ultraviolet radiation exposure, including tanning bed use, as well as host factors play a role in its development. The majority of cases are treated and cured with local therapies including surgery. Yet, the health care costs of diagnosis and treatment of BCCs in the US is substantial. In the United States, the cost of nonmelanoma skin cancer care in the Medicare population is estimated to be US$426 million per year. While rare, locally advanced BCCs that can no longer be controlled with surgery and/or radiation, and metastatic BCCs do occur and can be associated with significant morbidity and mortality. Vismodegib (GDC-0449), a smoothened inhibitor targeted at the hedgehog pathway, is the first US Food and Drug Association (FDA)-approved agent in the treatment of locally advanced, unresectable, and metastatic BCCs. This class of agents appears to be changing the survival rates in advanced BCC patients, but appropriate patient selection and monitoring are important. Multidisciplinary assessments are essential for the optimal care and management of these patients. For some patients with locally advanced BCC, treatment with a hedgehog inhibitor may eliminate the need for an excessively disfiguring or morbid surgery.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
United Kingdom 1 1%
Italy 1 1%
Unknown 78 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 16%
Researcher 12 15%
Student > Ph. D. Student 12 15%
Student > Bachelor 8 10%
Other 8 10%
Other 12 15%
Unknown 17 21%
Readers by discipline Count As %
Medicine and Dentistry 29 35%
Biochemistry, Genetics and Molecular Biology 15 18%
Agricultural and Biological Sciences 4 5%
Nursing and Health Professions 2 2%
Social Sciences 2 2%
Other 9 11%
Unknown 21 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2021.
All research outputs
#7,251,146
of 22,914,829 outputs
Outputs from Biologics: Targets & Therapy
#91
of 274 outputs
Outputs of similar age
#92,116
of 284,547 outputs
Outputs of similar age from Biologics: Targets & Therapy
#1
of 6 outputs
Altmetric has tracked 22,914,829 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 274 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,547 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them