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The utility of inflammatory markers to predict readmissions and mortality in COPD cases with or without eosinophilia

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, November 2015
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Title
The utility of inflammatory markers to predict readmissions and mortality in COPD cases with or without eosinophilia
Published in
International Journal of Chronic Obstructive Pulmonary Disease, November 2015
DOI 10.2147/copd.s90330
Pubmed ID
Authors

Dildar Duman, Emine Aksoy, Meltem Coban Agca, Nagihan Durmus Kocak, Ipek Ozmen, Ulku Aka Akturk, Sinem Gungor, Fatma Merve TEPETAM, Selma Aydogan Eroglu, Selahattin Oztas, Zuhal Karakurt

Abstract

COPD exacerbations requiring hospitalization increase morbidity and mortality. Although most COPD exacerbations are neutrophilic, approximately 10%-25% of exacerbations are eosinophilic. We aimed to evaluate mortality and outcomes of eosinophilic and non-eosinophilic COPD exacerbations and identify new biomarkers that predict survival. A retrospective observational cohort study was carried out in a tertiary teaching hospital from January 1, 2014 to November 1, 2014. All COPD patients hospitalized with exacerbations were enrolled in the study at their initial hospitalization and followed-up for 6 months after discharge. Electronic data were collected from the hospital database. Subjects' characteristics, hemogram parameters, CRP levels, neutrophil-to-lymphocyte ratio (NLR), platelet-to-mean platelet volume ratio on admission and discharge, length of hospital stay (days), readmissions, and mortality were recorded. Patients were grouped according to peripheral blood eosinophil (PBE) levels: Group 1, >2% PBE, eosinophilic; Group 2, non-eosinophilic ≤2%. Patient survival after hospital discharge was evaluated by Kaplan-Meier survival analysis. A total of 1,704 patients hospitalized with COPD exacerbation were included. Approximately 20% were classified as eosinophilic. Six-month mortality was similar in eosinophilic and non-eosinophilic groups (14.2% and 15.2%, respectively); however, the hospital stay length and readmission rate were longer and higher in the non-eosinophilic group (P<0.001 and P<0.01, respectively). CRP and NLR were significantly higher in the non-eosinophilic group (both P<0.01). The platelet-to-mean platelet volume ratio was not different between the two groups. Cox regression analysis showed that survival was negatively influenced by elevated CRP (P<0.035) and NLR (P<0.001) in the non-eosinophilic group. Non-eosinophilic patients with COPD exacerbations with high CRP and NLR values had worse outcomes than eosinophilic patients. PBE and NLR can be helpful markers to guide treatment decisions.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 64 98%

Demographic breakdown

Readers by professional status Count As %
Other 13 20%
Researcher 8 12%
Student > Master 8 12%
Student > Ph. D. Student 7 11%
Student > Bachelor 6 9%
Other 7 11%
Unknown 16 25%
Readers by discipline Count As %
Medicine and Dentistry 34 52%
Pharmacology, Toxicology and Pharmaceutical Science 4 6%
Nursing and Health Professions 2 3%
Computer Science 2 3%
Agricultural and Biological Sciences 2 3%
Other 3 5%
Unknown 18 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2015.
All research outputs
#4,854,183
of 6,562,576 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#590
of 805 outputs
Outputs of similar age
#143,702
of 209,310 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#55
of 69 outputs
Altmetric has tracked 6,562,576 research outputs across all sources so far. This one is in the 14th percentile – i.e., 14% of other outputs scored the same or lower than it.
So far Altmetric has tracked 805 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,310 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.