| Title |
Physical activity can improve cognition in patients with Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials
|
|---|---|
| Published in |
Clinical Interventions in Aging, September 2018
|
| DOI | 10.2147/cia.s169565 |
| Pubmed ID | |
| Authors |
Zhen Du, Yuewei Li, Jinwei Li, Changli Zhou, Feng Li, Xige Yang |
| Abstract |
Alzheimer's disease (AD) is mainly characterized by decline of cognitive functions such as memory and learning, which has a high prevalence and poor drug efficacy in treatment regimes. A systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to evaluate the effectiveness of exercise on cognitive function in patients diagnosed with AD. The bibliographic databases (PubMed, Cochrane Library and Embase, and Web of Science) and four Chinese databases (Wanfang data, CBM, CNKI, and VIP) were searched to identify RCTs published in any language between January 1, 1960, and January 1, 2018. Only peer-reviewed articles and RCTs were included. The collected data were analyzed by Review Manager (5.3). Overall, 869 patients diagnosed with AD were included from 13 RCTs. Patients in the intervention group received pure exercise interventions and a cognitive test. Although there was heterogeneity in intervention methods and cognitive measures among studies, meta-analysis (seven studies) supports positive effects of physical activity on cognitive function of patients with AD (mean difference [MD] =2.53, the 95% CI=0.84 to 4.22, test for overall effect: Z=2.93 [P=0.003]). Eight studies demonstrated that exercise improves cognitive function for individuals with AD. However, the remaining five studies did not display a beneficial effect of exercise on cognitive function in patients with AD. This meta-analysis and systematic review indicated that exercise intervention might improve the cognitive function of AD or slow down the decline of cognition; however, this relationship was not always true across studies. RCTs with clear intervention criteria, large samples, and long-term follow-up are needed in the future to demonstrate the benefits of exercise for cognitive function in AD patients. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 4 | 25% |
| United States | 3 | 19% |
| Australia | 2 | 13% |
| United Kingdom | 2 | 13% |
| Greece | 1 | 6% |
| Canada | 1 | 6% |
| Venezuela, Bolivarian Republic of | 1 | 6% |
| Unknown | 2 | 13% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 69% |
| Practitioners (doctors, other healthcare professionals) | 3 | 19% |
| Scientists | 2 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 363 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 363 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 66 | 18% |
| Student > Master | 38 | 10% |
| Student > Doctoral Student | 26 | 7% |
| Student > Ph. D. Student | 20 | 6% |
| Researcher | 16 | 4% |
| Other | 47 | 13% |
| Unknown | 150 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 12% |
| Nursing and Health Professions | 37 | 10% |
| Sports and Recreations | 21 | 6% |
| Neuroscience | 21 | 6% |
| Psychology | 16 | 4% |
| Other | 54 | 15% |
| Unknown | 169 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2023.
All research outputs
#1,878,516
of 25,385,509 outputs
Outputs from Clinical Interventions in Aging
#202
of 1,968 outputs
Outputs of similar age
#38,517
of 345,739 outputs
Outputs of similar age from Clinical Interventions in Aging
#7
of 55 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,968 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.1. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,739 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.