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Paroxetine ameliorates changes in hippocampal energy metabolism in chronic mild stress-exposed rats

Overview of attention for article published in Neuropsychiatric Disease and Treatment, November 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

Mentioned by

twitter
5 tweeters
facebook
1 Facebook page

Citations

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9 Dimensions

Readers on

mendeley
19 Mendeley
Title
Paroxetine ameliorates changes in hippocampal energy metabolism in chronic mild stress-exposed rats
Published in
Neuropsychiatric Disease and Treatment, November 2015
DOI 10.2147/ndt.s87089
Pubmed ID
Authors

Ahmed Abdel-tawab, Lobna Khedr, Noha Nassar, Ez eldin Eldenshary

Abstract

The molecular mechanisms underlying stress-induced depression have not been fully outlined. Hence, the current study aimed at testing the link between behavioral changes in chronic mild stress (CMS) model and changes in hippocampal energy metabolism and the role of paroxetine (PAROX) in ameliorating these changes. Male Wistar rats were divided into three groups: vehicle control, CMS-exposed rats, and CMS-exposed rats receiving PAROX (10 mg/kg/day intraperitoneally). Sucrose preference, open-field, and forced swimming tests were carried out. Corticosterone (CORT) was measured in serum, while adenosine triphosphate and its metabolites, cytosolic cytochrome-c (Cyt-c), caspase-3 (Casp-3), as well as nitric oxide metabolites (NOx) were measured in hippocampal tissue homogenates. CMS-exposed rats showed a decrease in sucrose preference as well as body weight compared to control, which was reversed by PAROX. The latter further ameliorated the CMS-induced elevation of CORT in serum (91.71±1.77 ng/mL vs 124.5±4.44 ng/mL, P<0.001) as well as the changes in adenos-ine triphosphate/adenosine diphosphate (3.76±0.02 nmol/mg protein vs 1.07±0.01 nmol/mg protein, P<0.001). Furthermore, PAROX reduced the expression of Cyt-c and Casp-3, as well as restoring NOx levels. This study highlights the role of PAROX in reversing depressive behavior associated with stress-induced apoptosis and changes in hippocampal energy metabolism in the CMS model of depression.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 21%
Student > Bachelor 3 16%
Professor > Associate Professor 3 16%
Other 3 16%
Professor 2 11%
Other 1 5%
Unknown 3 16%
Readers by discipline Count As %
Medicine and Dentistry 6 32%
Pharmacology, Toxicology and Pharmaceutical Science 4 21%
Neuroscience 2 11%
Psychology 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Other 1 5%
Unknown 4 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2015.
All research outputs
#4,230,999
of 14,535,828 outputs
Outputs from Neuropsychiatric Disease and Treatment
#644
of 2,442 outputs
Outputs of similar age
#69,482
of 238,686 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#25
of 78 outputs
Altmetric has tracked 14,535,828 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 2,442 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,686 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.