| Title |
Prefrontocerebellar transcranial direct current stimulation increases amplitude and decreases latency of P3b component in patients with euthymic bipolar disorder
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, November 2015
|
| DOI | 10.2147/ndt.s91625 |
| Pubmed ID | |
| Authors |
Francesco Saverio Bersani, Amedeo Minichino, Francesco Fattapposta, Laura Bernabei, Francesco Spagnoli, Daniela Mannarelli, Marta Francesconi, Caterina Pauletti, Alessandra Corrado, Lucilla Vergnani, Ines Taddei, Massimo Biondi, Roberto Delle Chiaie |
| Abstract |
Neurocognitive impairments have been observed in patients with bipolar disorder (BD) even during the euthymic phase of the disease, potentially representing trait-associated rather than state-associated characteristics of the disorder. In the present study, we used transcranial direct current stimulation (tDCS) applied to cerebellar and prefrontal cortices to improve the neurophysiological performances of patients with euthymic BD. Twenty-five outpatients with BD underwent open-label prefrontocerebellar tDCS for 3 consecutive weeks. Neurophysiological performances were assessed through the examination of the P3b and P3a subcomponents of P300 event-related potential at baseline and after stimulation. Compared to baseline, P3b component after tDCS showed significantly higher amplitude and shorter latency (latency: Fz P=0.02, Cz P=0.03, and Pz P=0.04; amplitude: Fz P=0.24, Cz P=0.02, and Pz P=0.35). In our sample of patients with euthymic BD, concomitant prefrontoexcitatory and cerebellar-inhibitory modulations led to improved brain information processing stream. This improvement may at least partially result from neuroplastic modulation of prefrontocerebellar circuitry activity. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 25% |
| United Kingdom | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 50% |
| Members of the public | 1 | 25% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 52 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 17% |
| Researcher | 9 | 17% |
| Student > Doctoral Student | 5 | 9% |
| Student > Master | 5 | 9% |
| Student > Bachelor | 3 | 6% |
| Other | 8 | 15% |
| Unknown | 14 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 13 | 25% |
| Psychology | 9 | 17% |
| Medicine and Dentistry | 6 | 11% |
| Computer Science | 2 | 4% |
| Unknown | 23 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2015.
All research outputs
#14,388,865
of 25,374,917 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,262
of 3,132 outputs
Outputs of similar age
#133,361
of 294,812 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#33
of 73 outputs
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